Analyzing HDL Lipoproteins in Patients with Depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between depression and cardiovascular disease by analyzing the functional and lipidomic properties of HDL lipoproteins in patients with moderate to severe depression compared to healthy controls. It aims to understand how lipid abnormalities may contribute to the increased cardiovascular risk observed in individuals suffering from depression. Participants will undergo assessments using the HDRS-17 depression scale and provide blood samples for analysis. The findings could shed light on potential mechanisms linking depression to cardiovascular issues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* FOR PATIENTS WITH RECURRENT DEPRESSION :

  * Patient who has provided oral consent
  * Adult with moderate to severe depression according to DSM-5 criteria (Hamilton HDRS-17 score ≥ 18), with a number of depressive episodes ≥ 3
* PATIENTS PRESENTING WITH A FIRST DEPRESSIVE EPISODE

  * Patient who has provided oral consent
  * Adult with moderate to severe characterized depression according to DSM-5 criteria (Hamilton HDRS-17 scale score ≥ 18) presenting with a first depressive episode.
* CONTROLS

  * Person who has provided oral consent
  * Adult who has never shown signs of depression

Exclusion Criteria:

* Person not affiliated with national health insurance
* Person subject to a measure of legal protection (curatorship, guardianship)
* Pregnant or breastfeeding women
* Adult unable to express consent
* Minors
* Person with a metabolic syndrome (according to NCEP/ATP-III criteria: 3 of the following 5 criteria: Waist circumference ≥ 102 cm in males and ≥ 88cm in females, Triglycerides \> 1.50 g/L, HDL-Cholesterol \< 0.40 g/L in H, HDL-Cholesterol \< 0.50 g/L in F, Blood pressure ≥130/85mmHg, Fasting blood glucose ≥ 1.10 g/L),
* Person with type 1 or type 2 diabetes,
* Person with a mild depressive episode (HDRS-17\<18),
* Person with concomitant antipsychotic treatment
* Person with bipolar disorder,
* Person with a moderate to severe alcohol use disorder according to DSM-5 criteria
* Person with schizophrenia,
* Person with a persistent delusional disorder,
* Person with an autism spectrum disorder.

Where it's running

• Chu Dijon Bourgogne
  Dijon, France Recruiting

Study contacts

• Study coordinator: Jean-Christophe CHAUVET-GELINIER
• Email: jean-christophe.chauvet-gelinier@chu-dijon.fr
• Phone: 03 80 29 37 69

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.