Analyzing genetic and clinical factors in Fuchs' Corneal Endothelial Dystrophy
Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in France. The French Fuchs' Follow-up Study (Phase 2), F3S2
This study is trying to see how genetic and clinical differences in people with Fuchs' Corneal Endothelial Dystrophy can help improve diagnosis and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Trial ID | NCT05742321 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between genotype and phenotype in patients with Fuchs' Corneal Endothelial Dystrophy (FECD) in France. By analyzing a large population, the study will investigate the diversity of clinical and histological forms associated with this condition. The methodology includes genotyping, histological analysis, and data collection to better understand the underlying mechanisms of FECD. The findings could lead to improved diagnostic and therapeutic strategies for affected individuals.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with Fuchs' Corneal Endothelial Dystrophy who require endothelial keratoplasty.
Not a fit: Patients under guardianship or curatorship will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of Fuchs' Corneal Endothelial Dystrophy, leading to better treatment options for patients.
How similar studies have performed: Other studies have shown success in analyzing genotype-phenotype relationships in corneal dystrophies, suggesting that this approach is promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * affiliated with or entitled to a social security scheme * Consent form to participate in the study signed * with an FECD certified by slit lamp examination * requiring an endothelial keratoplasty Exclusion Criteria: \- Patients under guardianship or curators
Where this trial is running
Saint-Etienne
- CHU Saint-Etienne — Saint-Etienne, France (Recruiting)
Study contacts
- Principal investigator: GILLES THURET, MD-PhD — Chu de Saint-Etienne
- Study coordinator: GILLES THURET, MD-PhD
- Email: gilles.thuret@univ-st-etienne.fr
- Phone: (0)477127793
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.