Analyzing genetic and clinical factors in Fuchs' Corneal Endothelial Dystrophy
Official title: Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in France. The French Fuchs' Follow-up Study (Phase 2), F3S2
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT05742321 · Data updated 2026-11-12
This study is trying to see how genetic and clinical differences in people with Fuchs' Corneal Endothelial Dystrophy can help improve diagnosis and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Status | Recruiting |
| Started | August 8, 2024 |
| Main results expected | June 1, 2026 |
| Study ends | September 1, 2026 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT05742321 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with Fuchs' Corneal Endothelial Dystrophy who require endothelial keratoplasty.
✕Probably not a fit
Patients under guardianship or curatorship will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between genotype and phenotype in patients with Fuchs' Corneal Endothelial Dystrophy (FECD) in France. By analyzing a large population, the study will investigate the diversity of clinical and histological forms associated with this condition. The methodology includes genotyping, histological analysis, and data collection to better understand the underlying mechanisms of FECD. The findings could lead to improved diagnostic and therapeutic strategies for affected individuals.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of Fuchs' Corneal Endothelial Dystrophy, leading to better treatment options for patients.
How similar studies have gone: Other studies have shown success in analyzing genotype-phenotype relationships in corneal dystrophies, suggesting that this approach is promising.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * affiliated with or entitled to a social security scheme * Consent form to participate in the study signed * with an FECD certified by slit lamp examination * requiring an endothelial keratoplasty Exclusion Criteria: \- Patients under guardianship or curators
Where it's running
-
CHU Saint-Etienne
Saint-Etienne, France Recruiting
Study contacts
- Principal investigator: GILLES THURET, MD-PhD — Chu de Saint-Etienne
- Study coordinator: GILLES THURET, MD-PhD
- Email: gilles.thuret@univ-st-etienne.fr
- Phone: (0)477127793
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.