Analyzing gene expression in heart tissue during surgery
Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery
This study looks at how certain genes affect heart tissue during surgery for aortic valve replacement to see how they respond to reduced blood flow.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 350 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT00985049 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how genetic variants influence gene expression in heart tissue during ischemia caused by cardiopulmonary bypass in patients undergoing aortic valve surgery. Researchers will collect small samples of heart tissue before and after ischemia and compare these with blood gene expression and the patients' genetic profiles. The goal is to understand the inflammatory response during surgery and the role of specific genes in this critical period.
Who should consider this trial
Good fit: Ideal candidates are patients over 20 years old undergoing aortic valve surgery with or without CABG surgery who will receive an apical left ventricular vent.
Not a fit: Patients who will not receive an apical left ventricular vent during their surgery will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of heart responses during surgery, potentially enhancing patient outcomes.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding gene expression related to cardiovascular conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged greater than 20 years * Undergoing aortic valve surgery with or without CABG surgery * Receive and apical vent as part of the surgery Exclusion Criteria: * Will not receive an apical left ventricular vent
Where this trial is running
Boston, Massachusetts
- Brigham and Women's Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Jochen D. Muehlschlegel, MD, MMSc, MBA — Johns Hopkins University
- Study coordinator: Jochen D Muehlschlegel, MD, MMSc, MBA
- Email: dmuehlsch@jhu.edu
- Phone: 4109558408
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.