Analyzing embryo outcomes based on ovarian follicle sizes and microRNA detection
Evaluation of the Outcomes of the Embryos Obtained From Different Follicle Sizes, and the miRNA Detection in the Spent Media of Their Blastocyst Culture
This study is testing if the size of ovarian follicles can help predict which embryos will develop into the healthiest blastocysts and how certain microRNAs in the culture media relate to embryo quality.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 55 (estimated) |
| Ages | 20 Years to 38 Years |
| Sex | Female |
| Sponsor | Acibadem University Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT05947526 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the outcomes of embryos derived from ovarian follicles of varying sizes. The goal is to predict which follicle size is most likely to yield the best quality blastocyst. Following the retrieval of blastocysts from these follicles, the study will investigate the expression of microRNA in the spent media of the blastocyst cultures, examining the correlation between embryo quality and miRNA expression levels.
Who should consider this trial
Good fit: Ideal candidates for this study are female patients aged 20-38 who are preparing for IVF treatment and have a specific number of follicles of adequate size.
Not a fit: Patients with polycystic ovary syndrome (PCO), endometriosis, or severe male factor infertility may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of embryo quality prediction, potentially improving IVF outcomes for patients.
How similar studies have performed: While similar studies have explored aspects of embryo quality and microRNA, this specific approach focusing on follicle size and miRNA detection is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged between 20-38 who are planned to have IVF treatment * On the day of trigger before the oocyte pick-up, patients having at least 5, and 14 at most follicles exceeding 11mm * Patient having BMI below 30 Exclusion Criteria: * PCO patients * Patients having endometriosis * Patients having male factor with severe oligoazoospermia
Where this trial is running
Istanbul
- Acibadem University Atakent Hospital — Istanbul, Turkey (Recruiting)
Study contacts
- Principal investigator: Nazli Albayrak, Md — Acıbadem University School of Medicine
- Study coordinator: Nazli Albayrak, Md
- Email: albayraknalzi@gmail.com
- Phone: 00905054111626
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.