Analyzing circular RNA in patients with acute ischemic stroke
Clinical Significance of Circulating circRNA in Acute Ischemic Stroke (CRAST)
This study is testing if certain circular RNA patterns in people who have had an acute ischemic stroke can help doctors detect and predict the condition better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | The Affiliated Hospital of Xuzhou Medical University Academic / other |
| Locations | 1 site (Xuzhou, Jiangsu) |
| Trial ID | NCT05098340 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the expression patterns of circular RNA (circRNA) in patients who have experienced an acute ischemic stroke compared to healthy controls. Using bioinformatics analysis and quantitative real-time polymerase chain reaction (qRT-PCR), the researchers will identify distinctive circRNA profiles that may serve as biomarkers for the detection and prognosis of acute ischemic stroke. The study will also establish a diagnostic or predictive model using logistic regression based on the identified circRNA patterns.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 years or older who have been diagnosed with acute ischemic stroke within 72 hours of symptom onset.
Not a fit: Patients with a history of hemorrhagic infarction, chronic kidney or liver diseases, peripheral arterial occlusive disease, active malignant disease, or inflammatory or infectious diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the development of novel biomarkers for early detection and improved prognosis of acute ischemic stroke.
How similar studies have performed: While the role of circRNA in ischemic stroke is an emerging field, similar studies have shown promise in identifying biomarkers for various conditions, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 years or older * Confirmed acute ischemic stroke by a diffusion-weighted imaging-position lesion on magnetic resonance imaging (MRI) and a new lesion on a brain computed tomography (CT) scan * Within 72 hours of symptom onset * Good performance status * Signed an approved informed consents Exclusion Criteria: * a history of hemorrhagic infarction, chronic kidney/liver diseases, peripheral arterial occlusive disease, active malignant disease, and inflammatory or infectious diseases
Where this trial is running
Xuzhou, Jiangsu
- Department of Neurology — Xuzhou, Jiangsu, China (Recruiting)
Study contacts
- Study coordinator: Xingzhi Wang, MD
- Email: wxz1220@126.com
- Phone: 0086-13852000759
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.