Analyzing cerebrospinal fluid biomarkers related to aging
Deputy Director of Department of Neurosurgery, the Second Affiliated Hospital of Zhejiang University School of Medicine；Professor；
This study is trying to see how certain proteins in the fluid around the brain change with age and if these changes can help spot early signs of neurodegenerative diseases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 0 Years to 90 Years |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06636201 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of cerebrospinal fluid (CSF) biomarkers in aging and neurodegenerative diseases. It aims to analyze CSF samples from various age groups to identify significant age-related changes in biomarkers such as amyloid-beta and Tau proteins. The study also seeks to develop a predictive model for early diagnosis of neurodegenerative diseases by quantifying CSF proteins and examining their dynamic changes across different disease stages. Additionally, a comprehensive database of CSF biomarkers will be created to support future research.
Who should consider this trial
Good fit: Ideal candidates include patients aged 0 to 90 years undergoing surgery under spinal anesthesia for non-neurological conditions.
Not a fit: Patients with existing neurological conditions such as Alzheimer's disease or Parkinson's disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enable early diagnosis and intervention for neurodegenerative diseases, improving patient outcomes.
How similar studies have performed: Other studies have shown promise in using CSF biomarkers for diagnosing neurodegenerative diseases, indicating a potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
1. Inclusion Criteria: * Patients aged 0 to 90 years will be selected for the study. * Patients admitted for surgery under spinal anesthesia due to non-neurological conditions, such as lower limb fractures or hemorrhoids. * Pediatric patients undergoing surgical treatment for tethered spinal cord syndrome. 2. Exclusion Criteria: * Patients with neurological conditions, including encephalitis, Parkinson's disease, Alzheimer's disease, hydrocephalus, brain tumors, and psychiatric disorders.
Where this trial is running
Hangzhou, Zhejiang
- The Second Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Junming Zhu, MD. phD
- Email: dr.zhujunming@zju.edu.cn
- Phone: 057187784815
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.