Analyzing cardiovascular risk factors during treadmill exercise tests

The Influence of Cardiovascular Risk Factors on Electrocardiographically and Hemodynamics Responses to Treadmill Exercise Test in Asymptomatically Subjects: a Clinical Perspective (ERGO-RISC)

Observational University of Sao Paulo · NCT05987891

This study looks at how different heart health risk factors affect the heart's response during treadmill exercise tests in healthy people.

Quick facts

Study typeObservational
Enrollment200 (estimated)
Ages18 Years to 90 Years
SexAll
SponsorUniversity of Sao Paulo Academic / other
Locations1 site (São Paulo, SP)
Trial IDNCT05987891 on ClinicalTrials.gov

What this trial studies

This observational study aims to investigate how various cardiovascular risk factors affect the electrocardiographic and hemodynamic responses during treadmill exercise tests in healthy and asymptomatic individuals. Participants will undergo a treadmill exercise test following the Ellestad protocol and provide information on their cardiovascular risk factors, including age, sex, family history of heart disease, and lifestyle habits. The study will compare the cardiovascular responses of individuals with multiple risk factors against those with few or none to identify significant differences in their exercise test outcomes.

Who should consider this trial

Good fit: Ideal candidates for this study are healthy, asymptomatic individuals who can complete a treadmill exercise test.

Not a fit: Patients with existing cardiovascular symptoms or those on medications affecting blood pressure or lipid levels may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could help identify individuals at higher risk for cardiovascular abnormalities, leading to earlier interventions and improved health outcomes.

How similar studies have performed: Previous studies have shown that assessing cardiovascular risk factors during exercise testing can provide valuable insights, suggesting this approach has been effective in similar contexts.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Subjects that can complete the treadmill exercise test with the Ellestad protocol with 6 minutes of recovery.

Exclusion Criteria:

* Use of remedies for blood pressure, glycemia, cholesterol, and serum lipids;
* Symptomatically subjects;
* Electrocardiogram that are not able to be interpreted;
* Blood pressure in rest state ≥180 mmHg and ≥110 mmHg, for systolic and diastolic, respectively.

Where this trial is running

São Paulo, SP

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Cardiovascular DiseasesCardiovascular AbnormalitiesHealthytreadmill exercise testasymptomatic subjectsCardiovascular risk factor
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.