Clinical trial Recruiting at 1 site Observational Ages 20 to 90

Analyzing cancer-related substances in lung cancer patients with brain metastasis

Official title: Comprehensive Profiling of Promising Biomarkers in Exosomes From Non-small Cell Lung Cancer With Central Nervous System Metastasis

Run by National Taiwan University Hospital · NCT06026735 · Data updated 2026-11-12

This study is testing whether certain substances found in the blood and spinal fluid of lung cancer patients with brain metastasis can help predict how the cancer will behave and how well treatments might work.

Quick facts

Study typeObservational
Ages20 Years to 90 Years
SexAll
Enrollment30 (estimated)
SponsorNational Taiwan University Hospital
Academic / other
Locations1 site (Taipei)
StatusRecruiting
StartedJanuary 13, 2023
Main results expectedDecember 2027
Study endsDecember 2027
Registry record updatedSeptember 7, 2023
Trial IDNCT06026735 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include non-small cell lung cancer patients diagnosed with brain or meningeal metastases who are scheduled for surgical intervention.

Probably not a fit

Patients without brain or meningeal metastases or those whose physical condition prevents surgical intervention may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on non-small cell lung cancer patients who have developed central nervous system metastasis. It involves collecting cerebrospinal fluid, blood samples, and tumor tissue from patients undergoing surgical procedures. The study aims to analyze the exosomes present in these samples and correlate them with clinical data to determine if these cancer cell-related substances can serve as predictive indicators for lung cancer metastasis and treatment efficacy.

Why it matters

Potential benefit: If successful, this study could provide new bioindicators for predicting lung cancer metastasis and treatment response, potentially improving patient management.

How similar studies have gone: While similar studies have explored cancer biomarkers, this specific approach focusing on exosomes in cerebrospinal fluid and tumor tissue is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- A. Non-small cell lung cancer patients diagnosed with brain metastases or meningeal metastases on brain computed tomography (CT) or magnetic resonance (MRI) images.

B. Patients with non-small cell lung cancer who are about to undergo surgical brain surgery, such as brain tumor resection, lumbar abdominal drainage, Euclidean storage, or ventriculoperitoneal drainage.

Exclusion Criteria:

\- A. Non-small cell lung cancer patients without brain metastases or meningeal metastases.

B. Physical condition does not allow surgical removal of the tumor.

Where it's running

  • National Taiwan University Hospital
    Taipei, Taiwan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.