Analyzing brain networks in epilepsy patients
Multi-scale Analysis of Physiological and Pathological Brain Networks by Simultaneous EEG-MEG-SEEG Recordings
This study is trying to learn more about how different parts of the brain work together in people with hard-to-treat epilepsy by using special recording techniques.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 240 (estimated) |
| Ages | 12 Years and up |
| Sex | All |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Trial ID | NCT03912155 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on understanding the physiological and pathological brain networks in patients with drug-resistant partial epilepsy. It utilizes simultaneous recordings from surface techniques like magnetoencephalography (MEG) and electroencephalography (EEG), alongside depth recordings from intracerebral stereotactic EEG (SEEG). The study aims to identify the most relevant mechanisms of interaction between brain regions and to determine if information from depth recordings can be inferred from surface data alone. This research builds on previous work demonstrating the feasibility of these combined recording techniques.
Who should consider this trial
Good fit: Ideal candidates include adults undergoing pre-surgical evaluation for drug-resistant partial epilepsy who are eligible for SEEG implantation.
Not a fit: Patients who are minors, pregnant, or under legal guardianship will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved preoperative assessments and treatment strategies for epilepsy patients.
How similar studies have performed: While this approach is innovative, previous studies have shown promise in using combined recording techniques for brain network analysis.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Inclusion criteria for patients * Patients for whom intracerebral electrode implantation is in progress as part of the pre-surgical evaluation of their drug-resistant partial epilepsy. * Patient informed, expressing his non-opposition (or legal representative (s), affiliated to a social security scheme * The medical examination is carried out as part of the medical follow-up of these patients * Inclusion criteria for control subjects • Informed subject, expressing his non-opposition or legal representative, affiliated to a social security scheme * Exclusion Criteria: Minors under 12 years * Pregnant or lactating women, * The adults under guardianship or under the protection of justice * Non-beneficiaries of a social security scheme * Persons deprived of their liberty by a judicial or administrative decision * Absence of informed consent
Where this trial is running
Marseille
- Assistance Publique Hôpitaux de Marseille — Marseille, France (Recruiting)
Study contacts
- Study coordinator: Fabrice Bartolomei, PU-PH
- Email: fabrice.bartolomei@ap-hm.fr
- Phone: 491384995
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.