Analyzing blood samples for pediatric solid tumors
Liquid Biopsies in Non-CNS Malignant Pediatric Solid Tumors
Children's Hospital Los Angeles · NCT05068583
This study is trying to see if blood tests can help track how well treatment is working for kids with solid tumors by looking for cancer-related material in their blood.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 320 (estimated) |
| Ages | 6 Months and up |
| Sex | All |
| Sponsor | Children's Hospital Los Angeles (other) |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT05068583 on ClinicalTrials.gov |
What this trial studies
This observational study aims to determine the feasibility of detecting tumor-derived material in the blood of pediatric patients with solid tumors. By collecting serial blood samples from patients at various stages of treatment, including before, during, and after therapy, the study will analyze cell-free DNA, RNA, and other tumor-related substances. The findings will be correlated with traditional disease evaluation methods to assess the effectiveness of liquid biopsies in monitoring disease progression and treatment response.
Who should consider this trial
Good fit: Ideal candidates include children aged 6 months to 21 years with newly diagnosed or relapsed/refractory high-grade solid tumors.
Not a fit: Patients with CNS malignancies or those under 6 months of age may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-invasive method for monitoring pediatric solid tumors, improving disease management and patient outcomes.
How similar studies have performed: While liquid biopsies have shown promise in adult cancers, their application in pediatric solid tumors is still being explored, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Newly diagnosed, relapsed, or refractory histologically confirmed high grade bone or soft tissue sarcoma or malignant renal, thyroid, germ cell, or hepatic tumors, OR * Healthy individual with no history of cancer or chronic medical problems and \< 21 years of age Exclusion Criteria: * CNS Malignancies * Individuals \< 6 months of age
Where this trial is running
Los Angeles, California
- Children's Hospital Los Angeles — Los Angeles, California, United States (RECRUITING)
Study contacts
- Principal investigator: Fariba Navid, MD — Children's Hospital Los Angeles
- Study coordinator: Fariba Navid, MD
- Email: fnavid@chla.usc.edu
- Phone: 323-361-2529
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pediatric Solid Tumor, Unspecified, Protocol Specific