Analyzing blood miRNAs to improve adenomyosis diagnosis
Official title: New Perspectives in Adenomyosis Pathogenesis With Epigenetic Analysis and miRNAs
Run by Université Catholique de Louvain · NCT06373822 · Data updated 2026-11-12
This study is trying to see if certain tiny molecules in the blood can help doctors diagnose adenomyosis more easily by comparing samples from patients with the condition to those without it.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 50 (estimated) |
| Sponsor | Université Catholique de Louvain Academic / other |
| Locations | 1 site (Brussels, Woluwe-Saint-Lambert) |
| Status | Recruiting |
| Started | March 21, 2024 |
| Main results expected | September 2031 |
| Study ends | September 2031 |
| Registry record updated | April 22, 2024 |
| Trial ID | NCT06373822 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are pre-menopausal women aged 18 and older who have been diagnosed with adenomyosis.
✕Probably not a fit
Patients with HIV or Hepatitis, those who have participated in another clinical study in the past year, or those presenting symptoms of endometriosis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify differentially expressed microRNAs (miRNAs) in the blood of patients with adenomyosis to develop new diagnostic methods. The researchers will collect blood samples from 25 adenomyosis patients and 25 healthy controls, isolating and analyzing miRNAs to detect potential differences. The hypothesis is that circulating miRNAs may serve as noninvasive biomarkers for diagnosing adenomyosis, based on previous findings in related conditions. The study will contribute to establishing a diagnostic panel that could be validated in larger populations in the future.
Why it matters
Potential benefit: If successful, this study could lead to a noninvasive diagnostic tool for adenomyosis, improving early detection and treatment options for patients.
How similar studies have gone: Previous studies have shown success in using circulating miRNAs as diagnostic tools in related conditions, suggesting potential for this approach in adenomyosis.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Pre-menopausal Exclusion Criteria: * HIV or Hepatitis-positive * having participated in another clinical study in the 12 months prior to recruitment * presenting symptoms of endometriosis
Where it's running
-
Cusl
Brussels, Woluwe-Saint-Lambert, Belgium Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Cannabinoid-based product for gynecologic pain in endometriosis, adenomyosis, or PID
This study tests a high-CBD, hemp-derived product against placebo in adults with gynecologic pain from endometriosis, adenomyosis, or PID over one week to see if it reduces pain and related symptoms.
-
Good pain consultation for endometriosis
This trial will test whether adding a 'good pain consultation' with early biopsychosocial pain education to usual care helps biological women with endometriosis manage pain and improve quality of life.
-
Effects of pelvic organ diseases on endometrial receptivity in infertile women
This study is trying to see how conditions like adenomyosis, fibroids, and endometriosis affect the ability of the uterus to support pregnancy in women who are having trouble getting pregnant.
-
Measuring L-PGDS levels in blood, urine, vaginal fluid and endometrial tissue
This project will test whether L-PGDS levels in blood, urine, vaginal fluid and uterine tissue differ between women with adenomyosis, other benign uterine conditions, and healthy controls.
-
Improving ultrasound diagnosis of adenomyosis
This study is trying to improve how well ultrasound can diagnose adenomyosis in women by looking at specific measurements of the uterus.
-
Understanding the risk factors for adenomyosis progression
This study is trying to find out what factors might make adenomyosis worse over time in women aged 18 to 55 who show signs of the condition on ultrasound.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.