Analyzing blood levels of Vitamin A and TREM2 in children with Autism Spectrum Disorder
Peripheral Blood VA/TREM2 Levels and Their Correlation Analysis With the Development and Autistic Symptoms in Children With ASD
This study looks at the blood levels of Vitamin A and TREM2 in children with Autism Spectrum Disorder to see if they are linked to the condition's symptoms and development.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 3 Years to 8 Years |
| Sex | All |
| Sponsor | Children's Hospital of Chongqing Medical University Academic / other |
| Locations | 1 site (Chongqing, Chongqing) |
| Trial ID | NCT06188429 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the correlation between peripheral blood levels of Vitamin A and TREM2 in children diagnosed with Autism Spectrum Disorder (ASD). By recruiting 50 typical children and 50 children with ASD, the study will analyze blood samples to explore potential biomarkers associated with the development and symptoms of ASD. The research will utilize the DSM-5 criteria for accurate diagnosis and will exclude participants with significant comorbid conditions that could confound results.
Who should consider this trial
Good fit: Ideal candidates for this study are children diagnosed with Autism Spectrum Disorder according to DSM-5 criteria, as well as typical children for comparative analysis.
Not a fit: Patients with significant comorbid neurological or physical disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could identify biomarkers that help in understanding the etiology of ASD and potentially lead to improved diagnostic and therapeutic strategies.
How similar studies have performed: While there have been studies exploring biomarkers in ASD, this specific correlation analysis of Vitamin A and TREM2 levels is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The Children's Health Department (Health Management Department) of Chongqing Medical University Affiliated Children's Hospital is recruiting 50 typical children and 50 children with ASD. Disease diagnosis will be conducted by professional doctors, and ASD diagnosis must comply with the DSM-5 diagnostic criteria. Exclusion Criteria: * Patients or their family members unable to cooperate with blood collection for testing are excluded. Exclusion criteria also involve a history of other neurological disorders, chromosomal diseases, genetic metabolic disorders, and other significant physical illnesses such as auditory or visual impairments, epilepsy, phenylketonuria, tuberous sclerosis, neurofibromatosis, severe head trauma, autoimmune diseases, and disorders related to the endocrine, cardiovascular, pulmonary, hepatic, or renal systems. Patients' legal guardians refusing to participate in the project are also excluded.
Where this trial is running
Chongqing, Chongqing
- Chongqing Medical University Affiliated Children's Hospital — Chongqing, Chongqing, China (Recruiting)
Study contacts
- Study coordinator: Wei Hua
- Email: weihua6280@163.com
- Phone: 18580476890
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.