Analyzing blood clots in stroke patients to improve treatment outcomes
Official title: Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT03268668 · Data updated 2026-11-12
This study looks at the blood clots from stroke patients who had a procedure to remove them to see if understanding their makeup can help improve treatment and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1200 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 12 sites (Bordeaux and 11 other locations) |
| Status | Recruiting |
| Started | July 13, 2017 |
| Main results expected | July 12, 2027 |
| Study ends | January 1, 2028 |
| Registry record updated | January 20, 2026 |
| Trial ID | NCT03268668 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have suffered a cerebral infarction due to arterial occlusion and have undergone thrombectomy.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or under legal protection measures will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients who have experienced an ischemic stroke and have undergone thrombectomy, a procedure to remove blood clots. It aims to collect and analyze the composition of the thrombus along with plasma biomarkers to understand their correlation with stroke etiology and prognosis. By examining the characteristics of the clots retrieved during treatment, the study seeks to identify patterns that could inform better management strategies for acute strokes. The findings may help clarify the relationship between thrombus composition and patient outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for stroke patients based on the specific characteristics of their blood clots.
How similar studies have gone: Previous studies have shown varying results regarding thrombus composition and stroke etiology, indicating that this area of research is still evolving and may yield novel insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years and older * Presenting with cerebral infarction following arterial occlusion * Treated for mechanical thrombectomy (whether performed or not) * Free, informed, and express consent of the patient or their relatives (emergency inclusion procedure) * For retrospective patients: thrombus already collected (according to the center's usual practice or for another research project). Exclusion Criteria: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman
Where it's running
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CHU de Bordeaux
Bordeaux, France Recruiting -
CHU Caen
Caen, France Recruiting -
Chu Limoges
Limoges, France Recruiting -
CHRU de Nancy
Nancy, France Recruiting -
CHU de Nantes
Nantes, France Recruiting -
Hôpital Lariboisière AP-HP
Paris, France Recruiting
Show 6 more locations
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Centre hospitalier Sainte-Anne
Paris, France Recruiting -
Fondation Ophtalmologique A. de Rothschild
Paris, France Recruiting -
Hôpital Foch
Suresnes, France Recruiting -
Hôpital d'Instruction des Armées Sainte-Anne
Toulon, France Recruiting -
CHRU Tours
Tours, France Recruiting -
CHU de Rennes
Rennes, France Completed
Study contacts
- Principal investigator: Jean-Philippe Désilles, MD — Fondation Ophtalmologique A. de Rothschild
- Study coordinator: Amélie Yavchitz, MD PhD
- Email: ayavchitz@for.paris
- Phone: 0148036454
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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-
Music therapy after stroke
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Endovascular therapy plus standard care vs standard care alone for distal and medium vessel strokes
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-
Inter-Limb Transfer after Acute Stroke
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Immersive Virtual Reality in Upper-Limb Rehabilitation After Stroke
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Cardiac MRI-based prediction tool for outcomes in dilated cardiomyopathy
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.