Analyzing blood clots in stroke patients to improve treatment outcomes
Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis
This study looks at the blood clots from stroke patients who had a procedure to remove them to see if understanding their makeup can help improve treatment and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 12 sites (Bordeaux and 11 other locations) |
| Trial ID | NCT03268668 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients who have experienced an ischemic stroke and have undergone thrombectomy, a procedure to remove blood clots. It aims to collect and analyze the composition of the thrombus along with plasma biomarkers to understand their correlation with stroke etiology and prognosis. By examining the characteristics of the clots retrieved during treatment, the study seeks to identify patterns that could inform better management strategies for acute strokes. The findings may help clarify the relationship between thrombus composition and patient outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have suffered a cerebral infarction due to arterial occlusion and have undergone thrombectomy.
Not a fit: Patients who are pregnant, breastfeeding, or under legal protection measures will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for stroke patients based on the specific characteristics of their blood clots.
How similar studies have performed: Previous studies have shown varying results regarding thrombus composition and stroke etiology, indicating that this area of research is still evolving and may yield novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years and older * Presenting with cerebral infarction following arterial occlusion * Treated for mechanical thrombectomy (whether performed or not) * Free, informed, and express consent of the patient or their relatives (emergency inclusion procedure) * For retrospective patients: thrombus already collected (according to the center's usual practice or for another research project). Exclusion Criteria: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman
Where this trial is running
Bordeaux and 11 other locations
- CHU de Bordeaux — Bordeaux, France (Recruiting)
- CHU Caen — Caen, France (Recruiting)
- Chu Limoges — Limoges, France (Recruiting)
- CHRU de Nancy — Nancy, France (Recruiting)
- CHU de Nantes — Nantes, France (Recruiting)
- Hôpital Lariboisière AP-HP — Paris, France (Recruiting)
- Centre hospitalier Sainte-Anne — Paris, France (Recruiting)
- Fondation Ophtalmologique A. de Rothschild — Paris, France (Recruiting)
- CHU de Rennes — Rennes, France (Completed)
- Hôpital Foch — Suresnes, France (Recruiting)
- Hôpital d'Instruction des Armées Sainte-Anne — Toulon, France (Recruiting)
- CHRU Tours — Tours, France (Recruiting)
Study contacts
- Principal investigator: Jean-Philippe Désilles, MD — Fondation Ophtalmologique A. de Rothschild
- Study coordinator: Amélie Yavchitz, MD PhD
- Email: ayavchitz@for.paris
- Phone: 0148036454
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.