Analyzing AMH levels in women with functional hypothalamic amenorrhea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze Anti-Müllerian Hormone (AMH) levels in women aged 15-34 who have been diagnosed with functional hypothalamic amenorrhea (FHA) for more than two years. The study hypothesizes that prolonged FHA may resemble primary hypogonadotropic hypogonadism due to a sustained interruption of gonadotropin release. After the resumption of the menstrual cycle, AMH levels will be reanalyzed to determine if they are higher, potentially challenging the notion that AMH is a reliable indicator of ovarian reserve in these patients. Participants will undergo venous sampling for AMH level assessment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 15-34 years.
* Diagnosis of functional hypothalamic amenorrhea (for at least 2 years).
* Signature of informed consent.

Exclusion Criteria:

* Polycystic ovary syndrome
* Taking oral contraceptives in the previous three months
* Other clinically relevant endocrinopathies
* positive MAP-test (Medroxyprogesterone acetate test)
* Estroprogestin replacement therapy
* Autoimmune disorders
* Failure to sign informed consent

Where it's running

• Rosanna Apa
  Rome, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.