Analysis of outcomes in patients with Hepatorenal Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes the outcomes of patients diagnosed with Hepatorenal Syndrome (HRS) at Methodist Dallas Medical Center over a four-year period. It focuses on patients who presented with HRS-AKI or developed HRS during their hospital stay, assessing their clinical characteristics and treatment responses. The study aims to identify patterns and outcomes associated with different classifications of HRS, including the impact of interventions like continuous renal replacement therapy and transjugular intrahepatic portosystemic shunts. By reviewing patient records, the study seeks to enhance understanding of HRS management in a clinical setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients \>18 years old that were hospitalized between April 1st 2019 and April 1st 2023 who either presented with HRS-AKI or developed a diagnosis of HRS during the hospital course. HRS-AKI will be defined based on the ICA criteria, described below:

  1. Presence of cirrhosis, acute liver failure, or acute-on-chronic liver failure
  2. An increase in serum Cr of ≥0.3 mg/dL within 48 hours or ≥50% from baseline value and/or urinary output ≤0.5 mL/kg of body weight for ≥6 hours (requires use of a urinary catheter)
  3. No full or partial response for ≥2 days of diuretic withdrawal and volume expansion with albumin (dosed at 1 g/kg of body weight/day)
  4. Absence of shock
  5. No current or recent treatment with nephrotoxic drugs
  6. Absence of parenchymal renal disease
  7. Suggestion of renal vasoconstriction based on FENa \<0.2%

Exclusion Criteria:

* 1\. HRS-AKI patients \<18 years of age 2. All patients hospitalized between April 1st 2019 and April 1st 2023 without a diagnosis of HRS-AKI.

Where it's running

• Liver Institute of Methodist Dallas Medical Center
  Dallas, Texas, United States Recruiting

Study contacts

• Principal investigator: Parvez Mantry, MD — Methodist Health System
• Study coordinator: Colette Ngo Ndjom, MS
• Email: MHSIRB@mhd.com
• Phone: 214-947-1281

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.