Analysis of molecular changes in endocrine tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect and analyze tumor specimens and healthy tissue from patients scheduled for surgery or biopsy of endocrine tumors, including those in the thyroid, parathyroid, adrenal gland, and pancreas. Researchers will focus on understanding the genetic, epigenetic, metabolomic, and proteomic profiles of these tumors to better distinguish between benign and malignant forms. The study seeks to improve detection and treatment options for endocrine neoplasms by identifying diagnostic and predictive markers. Participants will be evaluated based on specific inclusion criteria related to their tumor status and overall health.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:
* Participants who have an endocrine neoplasm based on radiographic and biochemical testing, or histologically/cytologically proven lesions of the thyroid, parathyroid, adrenal, extra-adrenal endocrine nests, paragangliomas, neuroblastomas, gastrointestinal

track and pancreas or participants with a described pre or potentially malignant condition that requires surgery or biopsy as a part of the standard of care treatment and/or follow up.

* Participants referred to the Endocrine Consult Service on other protocols for surgical evaluation of endocrine disorders based on radiographic and biochemical testing, or histologically/cytologically proven lesions of the thyroid, parathyroid, adrenal, extra-adrenal endocrine nests, paragangliomas, neuroblastomas and pancreas.
* Participants must have an ECOG performance score of 0-2.
* Participants must have physical examination parameters within acceptable limits by standard of practice guidelines prior to biopsy or surgery.
* Participants must be planning to undergo surgery or biopsy as part of their treatment plan. Note: Participants will not be enrolled exclusively for the procurement of tissue samples.
* Age \>= 4 years of age.

EXCLUSION CRITERIA:

None.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Naris Nilubol, M.D. — National Cancer Institute (NCI)
• Study coordinator: Kristine J Villaruel
• Email: ncieobinquiry@mail.nih.gov
• Phone: (240) 858-7033

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.