Analysis of cell surface markers in severe dry eye syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the changes in cell surface markers, specifically EMMPRIN, on conjunctival epithelial cells in patients with severe dry eye syndrome. It aims to describe the distribution of these markers before and after treatment initiation. The study includes patients with severe eye dryness and control subjects with normal tear break up times, allowing for a comparative analysis of the epithelial cell surface modifications. The findings could provide insights into the pathophysiology of dry eye syndrome and potential treatment responses.

Why it matters

Who can join: the full rules

Patients:

Inclusion criteria

* 18 years and over
* Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
* Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced

Exclusion criteria - Known pregnancy or breastfeeding

Control subjects:

Inclusion criteria

\- 18 years and over

Exclusion criteria

* Wearer of contact lenses
* Topical ocular treatment
* Known pregnancy or breastfeeding

Where it's running

• Fondation Ophtalmologique A de Rothschild
  Paris, France Recruiting

Study contacts

• Principal investigator: Eric GABISON — Fondation Ophtalmologique A. de Rothschild
• Study coordinator: Amélie YAVCHITZ
• Email: ayavchitz@for.paris
• Phone: 01.48.03.64.33

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.