AMAZE 1: NNC0487-0111 for adults with excess body weight

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

AMAZE 1 is a phase 3, randomized, placebo-controlled trial in which participants receive once-weekly subcutaneous injections of either NNC0487-0111 or a matched placebo. Treatment assignment is by chance and the placebo is matched to the active injection. Key eligibility excludes people with diagnosed diabetes or an HbA1c of 6.5% or higher and those with prior treatment with GLP‑1–based or amylin drugs. The study is sponsored by Novo Nordisk and is being conducted at several clinic sites in Florida and Georgia.

Why it matters

Who can join: the full rules

Key Inclusion Criteria:

* Male or female (sex at birth).
* Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study.
* History of at least one self-reported unsuccessful dietary effort to lose body weight.

Key Exclusion Criteria:

* HbA1c ≥ 6.5% (48 millimole per mole \[mmol/mol\]) as measured by the central laboratory at screening.
* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.

Where it's running

• South Broward Research LLC
  Miramar, Florida, United States Recruiting
• Clinical Neuroscience Solution
  Orlando, Florida, United States Recruiting
• Hope Clin Res & Wellness
  Conyers, Georgia, United States Recruiting
• Endeavor Health
  Skokie, Illinois, United States Recruiting
• Midwest Inst For Clin Res
  Indianapolis, Indiana, United States Recruiting
• StudyMetrix Research LLC
  City of Saint Peters, Missouri, United States Recruiting

+22 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Novo Nordisk
• Email: clinicaltrials@novonordisk.com
• Phone: (+1) 866-867-7178

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.