Alternative treatment for oral lichen planus using Daivobet ointment
A Novel Alternative Treatment Of Oral Lichen Planus
This study is testing if Daivobet ointment can help adults with oral lichen planus who haven't found relief from other treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 30 Years to 60 Years |
| Sex | All |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Mansoura, Dakahlia) |
| Trial ID | NCT06327620 on ClinicalTrials.gov |
What this trial studies
This project investigates a new treatment for oral lichen planus (OLP) by applying Daivobet ointment, which combines calcipotriol and betamethasone. The study will enroll 15 patients aged 30-60 years who have confirmed intra-oral erosive lichen planus and have not responded to existing therapies. Participants will apply the ointment three times daily for four weeks, with clinical assessments conducted at specified intervals to evaluate treatment efficacy. The study aims to provide a comprehensive understanding of the treatment's impact on this challenging condition.
Who should consider this trial
Good fit: Ideal candidates are adults aged 30-60 with bilateral intra-oral erosive lichen planus who have not responded to current therapies.
Not a fit: Patients with histological signs of dysplasia or those who have had hypersensitivity reactions to the study drug may not benefit from this treatment.
Why it matters
Potential benefit: If successful, this treatment could offer a new therapeutic option for patients suffering from oral lichen planus.
How similar studies have performed: While this approach is novel for oral lichen planus, similar treatments using Daivobet for other conditions have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Age between 30-60 years. Clinical signs and symptoms of bilateral intra-oral erosive lichen planus. History of unresponsiveness to currently available therapy. Histopathological confirmation by incisional biopsy. Willingness to topically apply Daivobet ointment in one side and topical steroid in the other side three times daily for 4 weeks. Exclusion Criteria: * Histological signs of dysplasia. Use of drugs possibly causing a lichenoid reaction. Lesions in contact with dental amalgam restorations. Any topical or systemic medications used in the treatment of oral lichen planus within four weeks before the study. History of hypersensitivity to the drug used in the current study.
Where this trial is running
Mansoura, Dakahlia
- Mansoura University, Faculty of Dentistry — Mansoura, Dakahlia, Egypt (Recruiting)
Study contacts
- Study coordinator: Wafaa saleh, Ph.D
- Email: wafaasaid@mans.edu.eg
- Phone: 01030539617
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.