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Clinical trial Recruiting at 1 site Interventional Ages 18 and up Men only

Alternative radiation treatments for prostate cancer patients

Official title: Prostate Cancer Patients Treated With Alternative Radiation Oncology Strategies

Run by University Hospital Heidelberg · NCT04083937 · Data updated 2026-11-12

This study is testing new types of radiation treatment for prostate cancer to see if they are safe and effective for patients who need extra help after surgery.

More Prostate Cancer trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexMen only
Enrollment897 (estimated)
SponsorUniversity Hospital Heidelberg
Academic / other
Locations1 site (Heidelberg)
StatusRecruiting
StartedSeptember 12, 2018
Main results expectedApril 2028
Study endsJanuary 2029
Registry record updatedMarch 9, 2026
Trial IDNCT04083937 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adult males with histologically confirmed prostate cancer who require prostate bed irradiation after surgery.

Probably not a fit

Patients with advanced prostate cancer (stage IV), those with lymphatic spread, or those who have previously undergone radiation therapy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates different radiation oncology strategies for treating prostate cancer, focusing on hypofractionated radiotherapy using both photons and protons, compared to standard normofractionated radiotherapy. It aims to determine the safety and feasibility of these approaches in patients requiring adjuvant or salvage treatment after prostatectomy. The study is prospective and randomized, allowing for a robust comparison of treatment outcomes. Participants will be monitored for their response to these radiation therapies over the course of treatment.

Why it matters

Potential benefit: If successful, this study could provide more effective and shorter radiation treatment options for prostate cancer patients, potentially improving their quality of life.

How similar studies have gone: Previous studies have shown success with hypofractionated radiotherapy approaches, indicating that this method is both safe and feasible.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* histology-proven prostate cancer with Gleason Score and PSA-value;
* indication for prostate bed irradiation (adjuvant/ salvage) after prostatectomy;
* Karnofsky-Index ≥ 70%
* age ≥ 18 years

Exclusion Criteria:

* androgen deprivation therapy
* lymphatic spread
* macroscopic tumor/ R2
* stage IV (M1)
* previous irradiation

Where it's running

  • University Hospital Heidelberg
    Heidelberg, Germany     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.