Alpha-ketoglutarate to improve recovery after coronary artery bypass

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, placebo-controlled Phase 4 trial gives alpha-ketoglutarate or matching placebo in the perioperative period to patients aged 50 and over undergoing elective CABG with cardiopulmonary bypass. Blood immune profiling including single-cell mass cytometry will be used before and after surgery to measure changes in immune cell signalling and inflammatory markers. Clinical recovery outcomes such as fatigue, pain, functional impairment, surgical site complications and organ dysfunction will be recorded and correlated with immune signatures. Key exclusions include current AKG use, active infection, recent cancer therapy, planned immunosuppression, certain psychiatric disorders, and pregnancy or breastfeeding.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Scheduled for elective CABG with cardiopulmonary bypass
2. Aged 50 years and above
3. Adequate cognitive function to be able to give informed consent

Exclusion Criteria

1. Patients already taking AKG as a supplement
2. Substance abuse disorder either untreated or treated
3. Post-traumatic stress disorder, bipolar disorder, Schizophrenia, or any other untreated or poorly controlled mental health or mood disorder, or history of hospitalization due to mental health condition in the past 3 years, cognitively impaired patients
4. HIV/AIDS
5. Patients undergoing or scheduled to undergo chemotherapy or any other treatment for malignancy
6. Patients scheduled for immunosuppressant therapy for transplant
7. Patients with an active infection requiring antibiotic or antiviral therapy
8. Pregnant women / planning to conceive / breastfeeding women
9. Patients who are taking chronic anti-inflammatory drugs e.g., NSAIDS
10. Patients who are hypersensitivity to AKG or placebo or any components of the respective tablets to be administered

Where it's running

• National University Hospital
  Singapore, Singapore, Singapore Recruiting
• Singapore General Hospital
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Lian Kah Ti — National University Hospital, Singapore
• Study coordinator: Lian Kah Ti
• Email: anatilk@nus.edu.sg
• Phone: 6567724200

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Early breathing therapy just one hour after CABG extubation

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• Structured inpatient physiotherapy before and after CABG for high-risk patients

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• Del Nido vs Blood Cardioplegia for Heart Muscle Health During CABG

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• Using blood flow measurements during bypass surgery to predict graft openness and recovery

  This trial will test whether using a device that measures blood flow during coronary bypass surgery helps surgeons ensure grafts stay open and improves recovery for adults having their first non-emergency multivessel CABG.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT07485738

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.