Almonertinib treatment for lung cancer patients with liver issues

a Phase II Studay to Assess the Efficacy and Safety of Almonertinib Therapy in Patients With Abnormal Liver Function After First/Second Generation TKI Treatment, or Almonertinib First-line Therapy in Patients With Basic Hepatopathy

This study is testing if a new lung cancer treatment called Almonertinib can help patients with advanced non-small cell lung cancer who also have liver problems.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 55 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: West China Hospital (Academic / other)
• Drugs / interventions: Almonertinib, radiation
• Locations: 1 site (Chendu, Sichuan)
• Trial ID: NCT05662813 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the efficacy and safety of Almonertinib in patients with advanced non-small cell lung cancer (NSCLC) who have abnormal liver function due to previous EGFR-TKI treatments or have basic hepatopathy. It is a single-arm, open-label Phase II trial that includes patients aged 18 and older with confirmed EGFR mutations. Participants will be observed for 24 months to assess treatment outcomes. The study aims to provide insights into the management of NSCLC in patients with liver complications.

Who should consider this trial

Good fit: Ideal candidates are adults with advanced EGFR-mutant NSCLC and abnormal liver function or basic hepatopathy who have not received prior systemic treatment.

Not a fit: Patients with normal liver function or those who have not been treated with EGFR-TKIs may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could improve outcomes for lung cancer patients with liver dysfunction, offering a new therapeutic option.

How similar studies have performed: While there is ongoing research in this area, the specific combination of Almonertinib for this patient population is novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

* Age at least 18 years.
* Locally advanced (IIIB and IIIC) or metastatic (IV) NSCLC.
* Tumor tissue samples or blood samples are confirmed to be EGFR sensitive mutations (including exon 19 deletion or L858R, both alone or coexist with other EGFR mutations).
* Patients have been treated with one kind of EGFR-TKIs and suffered from drug-induced liver injury, and have stopped EGFR-TKIs treatment before enrollment; or patients with basic hepatopathy (alcoholic liver disease, viral liver disease, metabolism related fatty liver disease, autoimmune liver disease, genetic metabolic liver disease), and patients can be treated with EGFR-TKIs after medical specialist evaluation, and no longger treated with hepatoprotective drugs (anti-inflammatory drugs, liver cell membrane repair protective agents, detoxification drugs, antioxidant drugs, cholagogic drugs) for 4 weeks before enrollment.
* ALT and AST ≤ 3 ULN, Child-Pugh grade A or B (≤ 9 points), and maintained for 4 weeks before enrollment (liver function evaluation criteria according to CTCAE 5.0) .
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3, and has not deteriorated at least 2 weeks, and the expected survival period is not less than 12 weeks.
* According to RECIST1.1, the patient has at least one intracranial target lesion and one extracranial target lesion. The requirements for target lesions are: measurable lesions that have not undergone local treatment such as irradiation or have clearly progressed after local treatment, with the longest diameter at baseline ≥10 mm (if it is a lymph node, the maximum short diameter is required to be ≥15 mm).

Exclusion Criteria:

* As judged by the investigator, patients with any serious or poorly controlled systemic diseases, such as poorly controlled hypertension, active bleeding-prone constitution, or active infection.
* Patients with any other malignant tumor in the past 5 years.
* Patients with prior drug-induced liver injury other than EGFR-TKIs.
* Patients with refractory nausea, vomiting or chronic gastrointestinal diseases, cannot swallow the study drug or who have received extensive intestinal resection, may affect the full absorption of Almonertinib.
* A history of interstitial lung disease, a history of drug-induced interstitial lung disease, a history of radiation pneumonitis requiring steroid therapy, or any evidence of clinically active interstitial lung disease.
* Before Almonertinib treatment, patients with unresolved residual toxicity from previous anti-tumor therapy greater than CTCAE level 3, except for hair loss.
* Meet any of the following cardiac examination results:

  1. The average value of QT interval (QTcF) corrected by Fridericia's formula obtained from 3 ECG examinations at rest\> 470 msec;
  2. Resting ECG suggests that there are various clinically significant rhythms, conduction or ECG morphological abnormalities that are judged by the investigator (such as complete left bundle branch block, 3 degree atrioventricular block, 2 degree atrium Ventricular block and PR interval\> 250 msec, etc.);
  3. There are any factors that increase the risk of QTc prolongation or arrhythmia events, such as heart failure, hypokalemia, congenital long QT syndrome, family history of long QT syndrome, or unexplained sudden death or prolonged QT of immediate family members under 40 Any concomitant drugs in the interval;
  4. Left ventricular ejection fraction (LVEF) \<50%.
* Insufficient bone marrow reserve or organ function, reaching any one of the following laboratory limits (no corrective treatment within 1 week before laboratory examination of blood draw):

  1. Absolute neutrophil count \<1.5×109 / L;
  2. Platelet count \<100×109 / L;
  3. Hemoglobin \<90 g/L (\<9 g/dL);
  4. Creatinine\>1.5×ULN and creatinine clearance rate\<50 mL/min (calculated by Cockcroft-Gault formula); Only when creatinine\>1.5×ULN, creatinine clearance rate needs to be confirmed;
  5. Serum albumin (ALB) \<28 g/L.
* Female with positive blood or urine pregnancy test results during lactation or within 3 days before the first administration of the study treatment.
* Active fungal, bacterial and/or viral infections requiring systemic treatment.
* Have a history of hypersensitivity to any active or inactive ingredients of Almonertinib or to drugs with similar chemical structure to Almonertinib or the same class of Almonertinib.
* Patients with decompensated cirrhosis, hepatic encephalopathy, hepatorenal syndrome, esophageal and gastric varices bleeding, and intractable ascites.
* Patients have treated with other three generations of EGFR-TKIs.
* Patients with any serious or uncontrolled disease, investigator judged that there are any patients with conditions that endanger the safety of the patient or interfere with the evaluation of the study.

Where this trial is running

Chendu, Sichuan

• West China Hospital，Sichuan University — Chendu, Sichuan, China (Recruiting)

Study contacts

• Principal investigator: Yanyang Liu — West China Hospital
• Study coordinator: Feng Luo, doctor

Conditions Non-small Cell Lung Cancer; EGFR; NSCLC; abnormal liver function; hepatopathy