Algorithm for diagnosing liver cancer mutations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop an immunohistochemical algorithm to identify specific mutations in hepatocellular carcinoma (HCC) that could guide molecular analysis for prognostic purposes. By examining the associations between biomarkers and genetic mutations in patients who have undergone liver resection, the study seeks to streamline laboratory resources and improve patient outcomes. Approximately 100 patients with known mutational profiles will be retrospectively evaluated using formalin-fixed and paraffin-embedded samples. The goal is to enhance the predictive capabilities of biopsies prior to surgery or therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Patients resected for HCC
* Availability of NGS data
* Availability of paraffin material for immunohistochemistry investigations

Exclusion Criteria:

* None

Where it's running

• IRCCS Azienda Ospedaliero-Universitaria di Bologna
  Bologna, Italy Recruiting

Study contacts

• Principal investigator: Francesco Vasuri, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
• Study coordinator: Francecso Vasuri, MD
• Email: francesco.vasuri2@unibo.it
• Phone: 0512143761

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.