Albumin plus furosemide versus furosemide alone for fluid overload in critically ill adults
"Comparison of Furosemide Versus Albumin Plus Furosemide in Increasing Urine Output in Critically Ill Patients: A Double-Blind Randomized Clinical Trial"
This test tries to see if giving albumin with furosemide helps adults in the ICU with fluid overload make more urine and protect kidney function compared with furosemide alone.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 56 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospital H+ Queretaro Academic / other |
| Locations | 1 site (Querétaro City, Querétaro) |
| Trial ID | NCT07417969 on ClinicalTrials.gov |
What this trial studies
This randomized interventional study compares two diuretic strategies in adult ICU patients with clinical fluid overload: furosemide alone versus furosemide combined with albumin. Participants are adults not on mechanical ventilation who are starting diuretics for fluid overload, and standardized dosing schedules are used. The trial measures urine output at 2 hours as the primary early endpoint and monitors renal perfusion markers, serum and urine biochemistry, and bedside ultrasound assessments of volume status. Hemodynamic variables, electrolyte changes, and estimated glomerular filtration rate are followed to capture short-term renal and circulatory effects.
Who should consider this trial
Good fit: Adult ICU patients (age ≥18) who are not mechanically ventilated, are starting diuretic therapy for clinical fluid overload, and are not on renal replacement therapy are the ideal candidates.
Not a fit: Patients already on dialysis, those with clinical hypovolemia or dehydration, those receiving palliative care, or those who refuse participation are unlikely to receive benefit from this protocol.
Why it matters
Potential benefit: If successful, adding albumin could increase early urine output and improve renal perfusion, potentially reducing fluid-related complications in the ICU.
How similar studies have performed: Previous smaller studies have shown mixed results—albumin can enhance diuresis in some hypoalbuminemic patients, but evidence in broad critically ill populations is limited and inconsistent.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults ≥ 18 years of age admitted to the intensive care unit (ICU) without mechanical ventilation. Patients for whom diuretic therapy will be initiated for the first time during the ICU stay due to clinical signs of fluid overload, as determined by the treating physician. Exclusion Criteria: Patients or family members who refuse participation in the study. Patients receiving palliative care. Patients with kidney failure requiring renal replacement therapy. Patients currently participating in another clinical research protocol. Patients with clinical evidence of hypovolemia or dehydration.
Where this trial is running
Querétaro City, Querétaro
- 76000 — Querétaro City, Querétaro, Mexico (Recruiting)
Study contacts
- Study coordinator: Alina Elizabeth Arechiga Casas, MD
- Email: alieliac26@gmail.com
- Phone: +52 8781360564
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.