Air introduction during pleural effusion drainage for trapped lung

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial evaluates the effectiveness of controlled air introduction into the pleural space during drainage of pleural effusions in patients with non-expandable lung (NEL). The study aims to determine if this air entrainment technique can reduce pain, improve patient satisfaction, and enhance fluid drainage compared to standard treatment. Participants will be randomly assigned to either the air entrainment group or the control group, with assessments made on pain relief, fluid volume drained, and overall patient experience. The trial is conducted at Cambridge University Hospital and includes adults scheduled for pleural effusion drainage.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older with a suspected or confirmed diagnosis of NEL and persistent pleural effusion.
* Patients who are scheduled for pleural effusion drainage as part of their standard care.
* Ability to adequately understand verbal or written information in English and provide informed consent in English.

Exclusion Criteria:

* Patients with a history of pleurodesis or other procedures that may affect pleural dynamics.
* Patients with active infections or other acute medical conditions that could interfere with the study.
* Patient with multifactorial pain and high baseline score pain defined as VAS \>= 5
* Patients requiring IPC
* Individuals with known contraindications to pleural drainage or air entrainment.
* Patients who cannot provide informed consent in English, do not adequately understand verbal or written information in English or have special communication needs.

Where it's running

• Addenbrooke's Hospital
  Cambridge, Cambridgeshire, United Kingdom Recruiting

Study contacts

• Study coordinator: Emilia M SWIETLIK, MD PhD
• Email: e.swietlik@nhs.net
• Phone: +447736750560

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Feasibility of a disposable flexible bronchoscope for thoracoscopy compared with a semi-rigid pleuroscope in pleural effusion

  This study tests whether a single-use flexible bronchoscope can be used safely and effectively for medical thoracoscopy in patients with pleural effusion, compared with the standard semi-rigid pleuroscope.

  Recruiting at 2 sites National University of Malaysia · Kuala Lumpur, Kuala Lumpur and 1 other locations · NCT07726784

• Ex Vivo Drug Response Testing in Lung Adenocarcinoma with Malignant Pleural Effusions

  This study tests whether the way cancer cells from pleural effusions respond to drugs outside the body can predict how patients will respond to treatment.

  Recruiting Sheba Medical Center · Ramat Gan, Israel · NCT07636252

• Intrapleural TolueneSulfonamide in malignant pleural effusion: early safety and activity

  This study tests intrapleural injections of TolueneSulfonamide in adults with malignant pleural effusion to see if it is safe and could help reduce the effusion.

  Recruiting Phase 1/2 China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT07332858

• Bubble PEP plus Segmental Breathing versus Incentive Spirometry for children with pleural effusion

  This trial will test whether bubble positive expiratory pressure with segmental breathing helps children aged 5–16 with pleural effusion breathe better than incentive spirometry.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07248774

• Once-daily intrapleural enzyme treatment for complicated pleural infections

  This will see if giving tPA and DNase once a day through a chest tube works as well as giving them twice a day for people with complicated pleural infections.

  Recruiting at 11 sites Phase 4 University of North Carolina, Chapel Hill · Little Rock, Arkansas and 10 other locations · NCT07095361

• Pleural fluid biomarker testing to help diagnose lung adenocarcinoma

  This project will test whether measuring new molecular markers in pleural fluid can help diagnose lung adenocarcinoma in adults who need thoracentesis.

  Recruiting Fu Jen Catholic University · New Taipei City · NCT07012759

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.