AI versus human-guided inferior vena cava ultrasound for checking hydration

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational pilot compares AI-guided IVC measurements with measurements made by a beginner and an experienced sonographer using two common views (subcostal and right intercostal) in healthy, euvolemic adults. Each participant receives ultrasound exams in the supine position and after a passive leg raise to mimic increased intravascular volume, with both sonographers blinded to each other's results. The beginner and experienced sonographers each perform two views before and after the maneuver, and the AI provides parallel indices, yielding eight human exams plus eight AI assessments per participant. The protocol includes a brief standardized training for sonographers and aims to measure feasibility and reliability of AI-derived IVC indices compared with human operators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy adults aged 18 years or older, 50% biological women

Exclusion Criteria:

* Pregnant or lactating women
* History of thrombosis of the inferior vena cava
* Major cardiovascular event in the last 3 months
* History of peripheral arterial disease of the legs
* History of heart failure of any grade
* History of atrial fibrillation or atrial flutter
* History of severe valvular disease
* History of renal failure
* History of liver cirrhosis
* History of chronic obstructive lung disease (COPD), chronic bronchitis, pulmonary emphysema
* History of diabetes mellitus
* History of arginine-vasopressin (AVP) disturbance
* Abdominal surgery within the last 3 month
* Volume loss (diarrhoea, vomiting, or bleeding) within the past 3 days
* Respiratory distress of any grade
* Any diuretic therapy, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs)
* Inability to follow procedures or insufficient proficiency in the study language
* Inability to provide informed consent
* Vital signs outside normal limits: tachycardia \>100 bpm, systolic blood pressure \<85 mmHg, or SpO2 \< 92%
* Employees or colleagues in a direct supervisory, subordinate, or collaborative relationship with the study team

Where it's running

• University Hospital Basel, Endocrinology, Diabetes and Metabolism
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Laura Potasso, Dr. med. sc. — University Hospital Basel, Endocrinology, Diabetes and Metabolism
• Study coordinator: Laura Potasso, Dr. med. sc.
• Email: laura.potasso@usb.ch
• Phone: +41 61 328 58 76

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.