AI-based glaucoma screening methods
Glaucoma Screening With Artificial Intelligence - A Randomized Clinical Trial Comparing Retinal Nerve Fiber Layer Optical Texture Analysis and Optic Disc Photography Assessment
This study is testing two new AI methods for spotting glaucoma to see if they work better and are more cost-effective than traditional screening methods for people in Hong Kong.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 3175 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 2 sites (Aberdeen and 1 other locations) |
| Trial ID | NCT06012058 on ClinicalTrials.gov |
What this trial studies
This clinical trial compares two artificial intelligence-enabled screening strategies for detecting glaucoma: ROTA assessment, which analyzes retinal nerve fiber layer optical textures, and optic disc photography. The study aims to evaluate the diagnostic performance of these methods against traditional optical coherence tomography assessments and trained graders. Additionally, it will investigate the cost-effectiveness of the ROTA AI assessment and estimate the prevalence of glaucoma in Hong Kong. The trial is crucial for determining the most effective screening strategy to prevent vision loss from glaucoma.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 50 years or older.
Not a fit: Patients who are physically incapacitated or unable to cooperate for clinical examinations will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and cost-effective screening methods for early detection of glaucoma, ultimately preserving patients' vision.
How similar studies have performed: Other studies have shown promise in using AI for glaucoma detection, but the specific application of ROTA assessment is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals aged 50 years or above Exclusion Criteria: * Physically incapacitated * Not able to cooperate for clinical examination or optical coherence tomography (OCT) investigation will be excluded
Where this trial is running
Aberdeen and 1 other locations
- Southern District Wah Kwai Community Centre — Aberdeen, Hong Kong (Recruiting)
- Kwun Tong District Health Centre — Kwun Tong, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Christopher Leung — The University of Hong Kong
- Study coordinator: Anita Yau
- Email: anitayky@hku.hk
- Phone: 39102673
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.