AI avatar-led mental health program to help employees with depression stay at work

Evaluating the Impact AI Avatar-led Mental Health Interventions for Keeping Employees in Work

Not applicable Interventional University of Roehampton · NCT07436117

This project will test whether an AI avatar-led, self-guided mental health program can help employees with depression feel better and remain working.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment50 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Roehampton Academic / other
Locations1 site (London)
Trial IDNCT07436117 on ClinicalTrials.gov

What this trial studies

About 50–80 adults with depressive symptoms will be randomly assigned to start an online AI avatar-led cognitive behavioural program immediately or to continue usual support and access the program later. The program is self-guided and delivered in several short sessions over a few weeks, with participants completing questionnaires on mood, anxiety, and work functioning before and after the study period. A subset of participants will be invited to brief interviews to describe their experience using the program and to report any concerns. The study will also monitor safety and acceptability in a working population.

Who should consider this trial

Good fit: Adults aged 18 or older living in the UK who currently have depressive symptoms (PHQ-9 score >5), are not receiving other therapy, and do not report frequent suicidal thoughts are ideal candidates.

Not a fit: People with frequent suicidal thoughts (PHQ-9 question 9 score >2), those already in other forms of therapy, or those with very severe, complex depression may not receive benefit from this self-guided program.

Why it matters

Potential benefit: If successful, the program could offer a scalable, accessible way for employees with depression to improve mood and workplace functioning without needing face-to-face therapy.

How similar studies have performed: Digital and online CBT programs have shown moderate benefits for depression in prior studies, but AI avatar-led delivery is relatively novel with limited direct evidence to date.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants will be eligible if they currently experience symptoms of depression (score above 5 on the PHQ-9)
* Participants should be aged 18 or above.
* Participants need to be resident in the UK.

Exclusion Criteria:

* Participants with frequent thoughts of suicide/self-harm will be excluded (scoring above 2 on Question 9 of the PHQ-9 "Thoughts that I would be dead or hurting myself in some way")
* Participants who are currently undergoing other forms of therapy will be excluded.

Where this trial is running

London

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Depression
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.