AI and 3D ultrasound mapping of mitral valve prolapse shape and function.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects intraoperative real-time 3D transesophageal echocardiography (RT3DE) during mitral valve repair to build an imaging dataset. Advanced deep learning algorithms will automatically segment valve substructures, extract anatomical landmarks, and generate high-resolution 3D valve models. Patient-specific finite element models will be created from the 3D data to simulate stresses, force transmission, and the biomechanical effects of different surgical repairs. When available, excised leaflet tissue will be preserved for histology, and all imaging datasets will be anonymized prior to analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (age \> 18 years old);
* Documented symptomatic degenerative MR with indication to MVP surgical repair, following the Heart Team decision;
* Periprocedural transesophageal 3DRTE of the MV apparatus, which is clinical standard modality for morphological assessment and guidance during MVP surgical repair;
* Signed informed consent.

Exclusion Criteria:

* Inadequate quality of 3DRTE imaging, e.g., due to inadequate patient-specific acoustic window;
* 3DRTE imaging with a temporal resolution of \< 20 Hz;
* Patient treated through prosthetic MV replacement.

Where it's running

• IRCCS Policlinico San Donato
  San Donato Milanese, Italy Recruiting

Study contacts

• Study coordinator: Francesco Sturla
• Email: francesco.sturla@grupposandonato.it
• Phone: +390252774353

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.