AGN-151607-DP to help close the belly wall after open midline ventral hernia repair

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 2, randomized, placebo-controlled trial will enroll about 200 adults undergoing open midline ventral hernia repair across roughly 30 U.S. sites. Participants are randomly assigned to receive a single intramuscular injection of AGN-151607-DP or matching placebo on Day 1, and are followed for adverse events and change in disease activity related to fascial closure. The study specifically examines whether the drug can enable primary fascial closure without requiring more complex surgical techniques. Total study duration for participants is approximately 25 months with scheduled follow-up visits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Midline ventral hernia requiring open surgical repair.

Exclusion Criteria:

* Medical condition that may put the participant at increased risk with exposure to AGN-151607-DP, including diagnosed muscular dystrophy (e.g., Duchenne's muscular dystrophy), myasthenia gravis, Eaton-Lambert syndrome, amyotrophic lateral sclerosis, mitochondrial disease, or any other significant disease which might interfere with neuromuscular function.
* History of abdominal or hernia repair surgery requiring hospitalization within 6 months prior to screening.

Where it's running

• CARI Clinical Trials INC /ID# 278844
  Riverside, California, United States Recruiting
• Medical Research Center /ID# 278680
  Miami, Florida, United States Recruiting
• Avanza Medical Research Center /ID# 278885
  Pensacola, Florida, United States Recruiting
• NorthShore University-Endeavor Health Evanston Hospital /ID# 277995
  Evanston, Illinois, United States Recruiting
• Mayo Clinic Hospital Rochester /ID# 278995
  Rochester, Minnesota, United States Recruiting
• Novant Health New Hanover Regional Medical Center /ID# 261979
  Wilmington, North Carolina, United States Recruiting

Study contacts

• Study coordinator: Abbvie Call Center
• Email: abbvieclinicaltrials@abbvie.com
• Phone: 844-663-3742

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.