Aerobic versus resistance exercise during hemodialysis to change the atherogenic index
Aerobic Versus Resistive Intradialytic Training Effect on Atherogeinc Index in Hemodialysis Patients
NA · Cairo University · NCT07045064
This trial will test whether doing aerobic or resistance exercise during dialysis can change the atherogenic index in adults on maintenance hemodialysis aged 40–60.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 40 Years to 60 Years |
| Sex | All |
| Sponsor | Cairo University (other) |
| Locations | 2 sites (Cairo, Select State and 1 other locations) |
| Trial ID | NCT07045064 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial will enroll 60 men and women aged 40–60 who have been on maintenance hemodialysis at least three months. Participants will be randomly assigned to one of three groups: intradialytic aerobic exercise, intradialytic resistive exercise, or a usual-care control group. Interventions are performed during regular dialysis sessions three times per week and the primary outcome is change in atherogenic index, with standard safety monitoring and exclusion of patients with unstable cardiovascular or severe systemic disease. The trial is conducted at the National Institute of Kidney and Urology, Mataria, under Cairo University oversight and informed consent and local ethics approvals are required.
Who should consider this trial
Good fit: Ideal candidates are adults 40–60 years old on maintenance hemodialysis three times weekly for at least three months with BMI 18.5–29.9 kg/m² and no major unstable cardiac, infectious, malignant, or neurologic conditions.
Not a fit: Patients with unstable angina, heart failure, uncontrolled hypertension, severe infection, malignant tumors, or significant neurologic disease are unlikely to benefit and are excluded for safety reasons.
Why it matters
Potential benefit: If successful, the interventions could lower atherogenic markers and potentially reduce cardiovascular risk in people on hemodialysis.
How similar studies have performed: Prior intradialytic exercise studies have shown improved fitness and some favorable changes in cardiovascular risk markers, but effects specifically on the atherogenic index are less well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: .Maintenance hemodialysis ≥ 3 months. .BMI will be ranged from 18.5 to 29.9 kg/m². .Age ≥ 40years and ≤ 60 years. .Hemodialysis 3 times a week. Exclusion Criteria: .patients suffered from any central and peripheral nervous system diseases. .patients suffered from serious complications, such as heart failure, severe infection and malignant tumor. .uncontrolled hypertension with systolic blood pressure ⩾200 mm Hg and/or diastolic blood pressure ⩾120 mm Hg. .unstable angina
Where this trial is running
Cairo, Select State and 1 other locations
- National Institute of Kidney and Urology, Mataria — Cairo, Select State, Egypt (NOT_YET_RECRUITING)
- National Institute of Kidney and Urology, Mataria — Cairo, Egypt (RECRUITING)
Study contacts
- Study coordinator: mariam rezk rezk, lecturer assistant
- Email: mariam.rezk112003@gmail.com
- Phone: 01280207863
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Chronic Kidney Disease Requiring Hemodialysis