Aerobic exercise during chemotherapy for colon cancer patients
Official title: Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer
Run by AdventHealth Translational Research Institute · NCT05773144 · Data updated 2026-11-12
This study is testing if doing aerobic exercise during chemotherapy can help people with stage II or III colon cancer get better results from their treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 219 (estimated) |
| Sponsor | AdventHealth Translational Research Institute Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 3 sites (Oakland, California and 2 other locations) |
| Status | Recruiting |
| Started | June 1, 2023 |
| Main results expected | May 1, 2027 |
| Study ends | May 1, 2027 |
| Registry record updated | January 7, 2026 |
| Trial ID | NCT05773144 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with stage II or III colon cancer who have completed surgery and are about to start chemotherapy.
✕Probably not a fit
Patients with metastatic colon cancer or those currently undergoing treatment for other cancers may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effects of aerobic exercise training on chemotherapy dose intensity in survivors of stage II or III colon cancer. Participants will be randomized to either an aerobic exercise program or an attention control group to assess the dose-response relationship. The study will include adults who have completed surgical resection and are about to begin chemotherapy, ensuring they meet specific health criteria. The goal is to determine if exercise can enhance the effectiveness of chemotherapy in this patient population.
Why it matters
Potential benefit: If successful, this study could improve chemotherapy outcomes and overall health for colon cancer survivors through structured aerobic exercise.
How similar studies have gone: Other studies have shown positive outcomes with exercise interventions during cancer treatment, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Histologically confirmed stage II or III colon cancer * Completed surgical resection with curative intent * Plan to initiate chemotherapy * Engage in \<60 minutes per week of moderate- to vigorous-intensity structured aerobic exercise * No planned major surgery during the study period * Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire * Can walk 400 meters * Can read and speak English * Ability to provide written informed consent * Provide written approval by qualified healthcare professional * Willing to be randomized Exclusion Criteria: * Evidence of metastatic colon cancer * Concurrently actively treated other (non-colon) cancer * Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks * Currently participating in another study with competing outcomes * Any other condition that, in the opinion of the investigator, would preclude participation or successful compliance with the protocol * Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol
Where it's running
-
Kaiser Permanente Northern California
Oakland, California, United States Recruiting -
AdventHealth
Orlando, Florida, United States Recruiting -
Dana-Farber Cancer Institute
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Justin C. Brown, Ph.D. — AdventHealth
- Study coordinator: Justin C. Brown, Ph.D.
- Email: Justin.Brown4@AdventHealth.com
- Phone: 4076095000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.