Advanced spinal radiation therapy using MR imaging

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of spinal stereotactic radiosurgery (SRSS) enhanced by Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) in treating spinal disease. The primary goal is to assess the local control of the target site after six months of treatment. Secondary objectives include measuring changes in epidural tumor volume and local control at one year. The study aims to improve treatment responses and enhance the quality of life for patients with spinal tumors.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA:

1. Age ≥ 18 years old
2. Radiographically documented disease of the spine within 4 weeks of registration (candidates with or without epidural disease allowed)
3. Candidate for spine SRS/SBRT as determined by treating Radiation Oncologist or Multidisciplinary Spine Conference review
4. Maximum of 3 contiguous vertebral levels involved with metastasis in the spine to be irradiated allowed
5. Diagnosis of cancer documented
6. Motor strength ≥ 4 out of 5 in the extremity affected by the level of spinal disease planned for radiation
7. Karnofsky Performance score (KPS) ≥ 40 or ECOG score ≤ 3

EXCLUSION CRITERIA:

1. Patients with highly radiosensitive histologies likely to respond to conventional radiation therapy alone (ie lymphoma, multiple myeloma, etc)
2. Patients who are unable to undergo MRI of the spine with contrast
3. Patients who are pregnant

Where it's running

• M D Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Debra N. Yeboa, MD — M.D. Anderson Cancer Center
• Study coordinator: Debra N. Yeboa, MD
• Email: dnyeboa@mdanderson.org
• Phone: (713) 563-2415

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.