Advanced MRI techniques for diagnosing benign neuronal tumors
Official title: High Resolution Imaging for Analysis of Multinodular and Vacuolating Neuronal Tumor of the Cerebrum
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT04285125 · Data updated 2026-11-12
This study is testing advanced MRI techniques to see if they can help doctors better diagnose benign brain tumors in adults, which could reduce the need for unnecessary surgeries.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 33 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 7 sites (Bordeaux, Bordeaux and 6 other locations) |
| Status | Recruiting |
| Started | March 5, 2020 |
| Main results expected | May 19, 2025 |
| Study ends | May 19, 2027 |
| Registry record updated | January 5, 2026 |
| Trial ID | NCT04285125 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old with suspected MVNT based on MRI findings.
✕Probably not a fit
Patients with contraindications to MRI or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on the characterization of multinodular and vacuolating neuronal tumors (MVNT) using advanced MRI techniques. It aims to improve diagnostic accuracy for these benign lesions, which often present with uncertain diagnoses leading to unnecessary invasive surgeries. By employing ultra-high resolution MRI sequences, the study seeks to establish precise diagnostic criteria for MVNT, potentially enhancing patient monitoring and treatment decisions. The study includes patients over 18 years old with suspected MVNT based on specific MRI criteria.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of benign neuronal tumors, reducing unnecessary surgeries and improving patient outcomes.
How similar studies have gone: While advanced MRI techniques have shown promise in other areas, this specific approach to MVNT characterization is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:
* Patient over 18 years of age
* Prospective inclusion of all patients with suspected MVNT on a first exploratory MRI: at least the 2 major criteria associated with at least 1 minor criterion will be required to fit into the definition of suspected MVNT:
* Major criteria :
* Multinomodular clustered appearance
* Franc hypersignal FLAIR/T2
* Minor criteria :
* No mass effect
* Hyposignal T1
* Having received informed information about the study and having given express consent to participate in the study
Exclusion Criteria:
* Contraindication to MRI
* Patient benefiting from a legal protection measure
* Pregnant or breastfeeding woman
Secondary exclusion criteria:
\- No characterization MRI done
Where it's running
-
CHU Rennes
Rennes, Rennes, France Recruiting -
Fondation A De Rothschild
Paris, France Recruiting -
Hôpital Laennec
Saint-Herblain, France Recruiting -
Groupe Hospitalier Pellegrin
Bordeaux, Bordeaux, France Active not recruiting -
CHU de Rouen
Rouen, Rouen, France Active not recruiting -
Hôpital Pierre Paul Riquet, CHU Purpan
Toulouse, Toulouse, France Active not recruiting
Show 1 more location
-
Centre Hospitalier Lyon Sud
Pierre-Bénite, France Active not recruiting
Study contacts
- Study coordinator: Amelie YAVCHITZ, PhD
- Email: ayavchitz@for.paris
- Phone: 0148036454
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
French validation of the SAHOT outcome tool after subarachnoid hemorrhage
This study tests whether a French version of the SAHOT questionnaire reliably measures outcomes in adults after subarachnoid hemorrhage.
-
Blood RNA biomarkers for ALS using neuron-derived extracellular vesicles
This will try to see if RNA signatures in neuron-derived extracellular vesicles from blood can identify biomarkers in adults with suspected sporadic ALS compared with healthy volunteers.
-
Probenecid for cluster seizures during presurgical epilepsy monitoring
This trial tests whether probenecid can help control clusters of seizures in people with focal epilepsy during presurgical video-EEG monitoring.
-
Onset of myopia in children who are not yet myopic
This study follows children aged 4 to under 9 with no myopia to see how many become nearsighted over time and what factors might influence that shift.
-
Using virtual reality to measure progress during low vision rehabilitation
This project will test a 20-minute virtual reality test (VisionumVR on a Meta Quest 3) to measure functional vision in people with low vision who are starting or undergoing orthoptic rehabilitation.
-
Renal Involvement in Wilson's Disease
This study tests how Wilson's disease affects the kidneys and who might be at risk for kidney problems.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.