Advanced MRI techniques for diagnosing benign neuronal tumors
High Resolution Imaging for Analysis of Multinodular and Vacuolating Neuronal Tumor of the Cerebrum
This study is testing advanced MRI techniques to see if they can help doctors better diagnose benign brain tumors in adults, which could reduce the need for unnecessary surgeries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 33 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 7 sites (Bordeaux, Bordeaux and 6 other locations) |
| Trial ID | NCT04285125 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the characterization of multinodular and vacuolating neuronal tumors (MVNT) using advanced MRI techniques. It aims to improve diagnostic accuracy for these benign lesions, which often present with uncertain diagnoses leading to unnecessary invasive surgeries. By employing ultra-high resolution MRI sequences, the study seeks to establish precise diagnostic criteria for MVNT, potentially enhancing patient monitoring and treatment decisions. The study includes patients over 18 years old with suspected MVNT based on specific MRI criteria.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with suspected MVNT based on MRI findings.
Not a fit: Patients with contraindications to MRI or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of benign neuronal tumors, reducing unnecessary surgeries and improving patient outcomes.
How similar studies have performed: While advanced MRI techniques have shown promise in other areas, this specific approach to MVNT characterization is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
* Patient over 18 years of age
* Prospective inclusion of all patients with suspected MVNT on a first exploratory MRI: at least the 2 major criteria associated with at least 1 minor criterion will be required to fit into the definition of suspected MVNT:
* Major criteria :
* Multinomodular clustered appearance
* Franc hypersignal FLAIR/T2
* Minor criteria :
* No mass effect
* Hyposignal T1
* Having received informed information about the study and having given express consent to participate in the study
Exclusion Criteria:
* Contraindication to MRI
* Patient benefiting from a legal protection measure
* Pregnant or breastfeeding woman
Secondary exclusion criteria:
\- No characterization MRI done
Where this trial is running
Bordeaux, Bordeaux and 6 other locations
- Groupe Hospitalier Pellegrin — Bordeaux, Bordeaux, France (Active_not_recruiting)
- CHU Rennes — Rennes, Rennes, France (Recruiting)
- CHU de Rouen — Rouen, Rouen, France (Active_not_recruiting)
- Hôpital Pierre Paul Riquet, CHU Purpan — Toulouse, Toulouse, France (Active_not_recruiting)
- Fondation A De Rothschild — Paris, France (Recruiting)
- Centre Hospitalier Lyon Sud — Pierre-Bénite, France (Active_not_recruiting)
- Hôpital Laennec — Saint-Herblain, France (Recruiting)
Study contacts
- Study coordinator: Amelie YAVCHITZ, PhD
- Email: ayavchitz@for.paris
- Phone: 0148036454
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.