Advanced MRI techniques for detecting causes of focal epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of high-resolution multi-parametric magnetic resonance imaging (MRI) in identifying subtle lesions responsible for focal epilepsy in patients who have previously undergone standard MRI without revealing any abnormalities. By utilizing advanced imaging techniques, including T1-weighted inversion recovery sequences, the study aims to enhance the detection rate of structural lesions that may contribute to drug-resistant epilepsy. The research focuses on patients with a confirmed diagnosis of focal epilepsy and aims to apply these advanced imaging protocols in a local clinical setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Consecutive patients with drug-resistant focal epilepsy fulfilling the following criteria -

  1\. Diagnosis of focal epilepsy with a probable site identified, as defined by concordant results from any TWO of the following:
* Clinical seminology compatible with focal epilepsy.
* Electroencephalography pointing towards a specific site for focal epilepsy.
* Positive ictal brain scintigraphy with SPECT-CT correlation. AND 2. Previous MRI (at least one study with protocol tailored for epilepsy) which did not reveal accountable focal lesion.

AND 3. Able to consent for MRI examination (if patient under age of 18, consent for MRI will be obtained from guardian). Patients will be provided information leaflets to read on, and written consent before taking part in this study and MRI examination.

Exclusion Criteria:

* Patients who are contraindicated to magnetic resonance imaging (such as due to underlying MRI incompatible metallic implants)
* Patients who cannot cooperate for MRI scanning.
* Patients show are unable to provide informed consent.

Where it's running

• Gerald Choa MRI Center
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Hanson Leung, MBBS (HK) — Chinese University of Hong Kong
• Study coordinator: Hanson Leung, MBBS (HK)
• Email: lhs655@ha.org.hk
• Phone: 35051009

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating zonisamide for treating focal epilepsy in children

  This study is testing if adding zonisamide to the treatment of children aged 1-14 with hard-to-control focal epilepsy can help reduce their seizures and improve their thinking skills.

  Recruiting Phase 4 Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT06967012

• Evaluating the safety of cenobamate for Japanese patients with partial seizures

  This study is testing how safe cenobamate is for Japanese patients with partial seizures who have already taken part in a related study.

  Recruiting at 29 sites Phase 2 Ono Pharmaceutical Co., Ltd. · Ehime and 28 other locations · NCT06590896

• Postpartum exercise to improve heart and metabolic health in women at high risk for preeclampsia

  This pilot study tests whether a 12‑week postpartum exercise program can improve heart health and metabolic markers in women who were at high risk for preeclampsia.

  Recruiting Chinese University of Hong Kong · Hong Kong, Hong Kong · NCT07921173

• Ultrasound-guided microwave ablation for benign thyroid nodules

  This study tests whether using ultrasound-guided microwave ablation to shrink benign thyroid nodules under local anesthesia is safe and effective, compared with traditional surgery.

  Recruiting Chinese University of Hong Kong · Shatin · NCT07906821

• Romiplostim added to standard ESA therapy in adults on hemodialysis with ESA-resistant anemia

  This phase 2 study tests whether adding romiplostim to ongoing ESA treatment is safe and tolerable for adults on dialysis whose anemia does not respond well to ESAs.

  Recruiting Phase 2 Chinese University of Hong Kong · Hong Kong · NCT07854561

• Metomidate PET-CT vs Usual Care for Primary Aldosteronism

  This study tests whether [11C] metomidate PET-CT can help orient treatment for people with primary aldosteronism compared with the usual adrenal venous sampling approach.

  Recruiting Chinese University of Hong Kong · Shatin · NCT07814105

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.