Advanced imaging techniques for eye diseases

oCular Examination at Cell RESolution With Optical TransmissionTomography

This study is testing new imaging techniques for eye diseases to see if they can help doctors better understand and manage conditions like glaucoma and cataracts in both healthy people and patients.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 300 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (other)
• Locations: 1 site (Paris)
• Trial ID: NCT06976034 on ClinicalTrials.gov

What this trial studies

This study explores the use of innovative imaging technologies, specifically Optical Transmission Tomography (OTT), alongside Optical Coherence Tomography (OCT) and Specular Microscopy (SM), to enhance the examination of ocular diseases. Healthy subjects and patients with ocular disorders will undergo imaging sessions at baseline and follow-up visits over a period of up to four years. The goal is to improve the resolution and speed of ocular imaging, which may lead to better understanding and management of conditions like glaucoma and cataracts.

Who should consider this trial

Good fit: Ideal candidates include individuals aged 18 to 80 with ocular diseases affecting the cornea, lens, or glaucoma, as well as those requiring refractive surgery.

Not a fit: Patients with active contagious eye diseases or those unable to maintain a still position during examinations may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic capabilities and treatment outcomes for patients with ocular diseases.

How similar studies have performed: While this approach utilizes established imaging technologies, the specific combination and application of OTT in this context is relatively novel.

Eligibility criteria

Inclusion Criteria:

For Patients:

* 200 subjects aged 18 to 80 years;
* Male or female;
* with an ocular disease affecting the cornea, ocular surface, lens (cataract) or glaucoma, or requiring refractive surgery or post-refractive surgery follow-up;
* Are covered by the French Assurance Maladie;
* Have signed an express, free and informed consent form.

For Healthy volunteers:

* 100 subjects aged 18 to 80 years;
* Male or female;
* Healthy subjects with no known pathology directly or indirectly affecting ocular structures;
* Covered by the French Assurance Maladie.
* Having signed an express, free and informed consent form.

Exclusion Criteria:

For all participants:

* Inability to hold a still position on a standard ophthalmic chin rest;
* Conjunctivitis or other contagious contact disease in active phase;
* Having an implanted pacemaker or other electronic medical device;
* Having a predisposition to iridocorneal angle closure;
* Vulnerable persons or persons under legal protection (pregnant or breast-feeding women; persons under guardianship,

Where this trial is running

Paris

• Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts — Paris, France (RECRUITING)

Study contacts

• Principal investigator: Nacim BOUHERAOUA, PU-PH — Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
• Study coordinator: Nabil BROUK

Conditions: Glaucoma Associated With Other Ocular Disorders