Adolescent Self-Injury Intervention Skills Training (ASIST) vs TAU

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare ASIST to treatment as usual in adolescents aged 12–17 with NSSI. They will measure changes in psychological, clinical, and behavioral outcomes, and explore biological markers like cortisol, beta-endorphin, and brain activity. The study will also use machine learning to predict which teens respond to treatment. Safety and tolerability will be monitored throughout. Data will come from multiple sites affiliated with Seoul National University and its collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adolescents aged 12 to 17 years.
* Adolescents who meet the DSM-5 diagnostic criteria for non-suicidal self-injury (NSSI) and report at least one episode of self-injurious behavior within the past month.
* Adolescents who report at least one episode of self-injurious behavior within the past year, as assessed by the Self-Harm Inventory (SHI).
* Participants currently taking psychiatric medication must have maintained a stable dosage for at least one month prior to enrollment.

Exclusion Criteria:

* History of psychotic disorders, including schizophrenia, or bipolar disorder.
* History of eating disorders.
* Presence of developmental disorders, including autism spectrum disorder.
* History of alcohol or substance abuse within the past six months.
* Presence of coexisting medical or neurological conditions.
* Changes in psychiatric medication dosage within one month prior to enrollment.
* History of an actual suicide attempt within the past year, as assessed by the Columbia-Suicide Severity Rating Scale (C-SSRS).

Where it's running

• Seoul National University Hospital
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Jae-Won Kim, MD, PhD — Seoul National University and Seoul National University Hospital
• Study coordinator: Jae-Won Kim, MD, PhD
• Email: kimjw412@snu.ac.kr
• Phone: 82-2-2072-3648

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• National Highly Specialized Care for adults with treatment-resistant self-harm and eating disorders (Substudy 1)

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• Triple-daily 15 mA tACS for adolescent nonsuicidal self-injury

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• Cognitive-behavioral therapy for Chinese adolescents with self-injury

  This study is testing a new online and video therapy program to help Chinese teens aged 12-17 who hurt themselves learn to manage their emotions better.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.