Adjuvant immune checkpoint inhibitors after liver cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective cohort study assessing adjuvant immune checkpoint inhibitor therapy versus active surveillance in patients who have undergone curative hepatectomy for hepatocellular carcinoma. It focuses on individuals with high risk of recurrence, including factors like large tumor size or vascular invasion, and uses real-world clinical data. The study aims to observe safety and efficacy in routine practice, complementing randomized trials. It is led by Guangxi Medical University and conducted at a single site in Nanning, China. No randomized design is specified, and results will inform future use in the postoperative setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Underwent curative hepatectomy;
* Diagnosis of HCC was confirmed by postoperative histopathology;
* Liver function Child-Pugh A or B;
* Performance status score 0 or 1
* With high risk factor of HCC recurrence, such as tumor size ≥ 5 cm, multinodular, macrovascular invasion or microvascular invasion;

Exclusion Criteria:

* Receive neoadjuvant immune checkpoint inhibitors therapy.

Where it's running

• Jian-Hong Zhong
  Nanning, Guangxi, China Recruiting

Study contacts

• Study coordinator: Jian-Hong Zhong, PhD
• Email: zhongjianhong@gxmu.edu.cn
• Phone: +86 15296561499

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.