Adding polyphenol-rich pulses to your daily diet to improve skin health
Official title: To Determine Whether Adding Polyphenol-rich Pulses to Daily Diet Improves Skin Health by Reshaping the Skin Microbiome and Lipids, and Reducing Oxidative Stress and Inflammation in Women
Run by University of Florida · NCT06538415 · Data updated 2026-11-12
This 12-week test will see if adding a daily serving of polyphenol-rich pulses improves skin health in women aged 45–65.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 45 Years to 65 Years |
| Sex | Women only |
| Enrollment | 50 (estimated) |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Status | Recruiting |
| Started | May 12, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | July 2, 2026 |
| Trial ID | NCT06538415 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal participants are women aged 45–65 with BMI 18.5–29.9, body weight ≥110 pounds, Fitzpatrick skin types I–III, not pregnant or breastfeeding, and able to follow the assigned diet and attend visits in Gainesville, FL.
✕Probably not a fit
People with impaired fasting glucose, frequent alcohol use, a history of skin cancer, habitual high fruit intake, use of medications or supplements that affect outcomes, pregnant or breastfeeding women, or those outside the specified skin types or BMI range may not benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, parallel-design dietary trial will enroll about 48–50 women aged 45–65 and compare a daily serving of cooked mixed polyphenol-rich pulses (lentils, red kidney beans, black beans, pinto beans) against a white rice control diet over 12 weeks. Researchers will measure skin appearance and barrier function, analyze skin microbiome and epidermal lipids, and track markers of oxidative stress and inflammation. The trial will look for correlations between changes in the microbiome/lipids and improvements in skin measures. Participants must meet BMI and skin-type criteria and attend in-person visits at the trial site.
Why it matters
Potential benefit: If successful, adding polyphenol-rich pulses could improve visible skin appearance and barrier function and lower markers of oxidative stress and inflammation.
How similar studies have gone: Preliminary data showed six weeks of cranberry juice improved some skin measures and correlated with microbiome changes, but direct clinical evidence for polyphenol-rich pulses affecting human skin is currently lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI (18.5-29.9) * Body weight ≥110 pounds * Fitzpatrick skin type 1,2 and 3. Exclusion Criteria: * pregnancy * breast-feeding * impaired fasting glucose * frequent alcohol use * history of skin cancer * sunbathing and the use of tanning bed, intake of vitamin/mineral supplements * habitual high intake of fruits (≥ 2 cups daily) * intake of medication that might influence the outcome of the study
Where it's running
-
Food Science and Human Nutrition
Gainesville, Florida, United States Recruiting
Study contacts
- Study coordinator: Liwei Gu, PhD
- Email: lgu@ufl.edu
- Phone: (352)2943730
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.