Adding platelet-rich plasma (PRP) to donor sperm during freezing
Official title: Effect of Platelet-rich Plasma (PRP) on the Quality of Donor Semen During Cryopreservation
Run by Instituto Valenciano de Infertilidad, IVI Alicante · NCT07504575 · Data updated 2026-11-12
This study will try adding platelet-rich plasma (PRP) to sperm during freezing to see if it improves motility after thawing for men providing samples.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 35 Years |
| Sex | Men only |
| Enrollment | 20 (estimated) |
| Sponsor | Instituto Valenciano de Infertilidad, IVI Alicante Academic / other |
| Locations | 1 site (Alicante, Alicante) |
| Status | Recruiting |
| Started | February 10, 2026 |
| Main results expected | September 30, 2027 |
| Study ends | January 30, 2028 |
| Registry record updated | April 17, 2026 |
| Trial ID | NCT07504575 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Men aged 18–35 with semen showing >50 million progressively motile sperm and >4% normal morphology, without personal or hereditary pathology or psychological/behavioral disorders, are ideal candidates.
✕Probably not a fit
Men with semen parameters below the inclusion thresholds, with relevant medical or hereditary conditions, or outside the specified age range are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will compare thawed semen samples frozen with differing concentrations of autologous PRP (including 1%, 2% and a primary 5% concentration) against control samples without PRP. The primary outcome is a difference in progressive motility between control and samples frozen with 5% PRP, with secondary analyses of other semen quality parameters and correlations with PRP platelet counts. Semen samples meeting inclusion criteria will be processed, frozen, thawed, and analyzed using standard laboratory measures of motility, viability, morphology, and membrane integrity. The study focuses on ex vivo modifications of the freezing medium rather than clinical pregnancy outcomes.
Why it matters
Potential benefit: If successful, adding PRP to the freezing medium could improve post-thaw sperm motility and overall semen quality, potentially helping assisted reproduction outcomes.
How similar studies have gone: Previous small studies have reported that PRP components can improve post-thaw motility, viability, and membrane integrity, but the evidence is limited and not yet definitive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Age from 18 to 35 years Concentration higher than 50 million progressively motile sperm. Morphology: more than 4% normal sperm shapes. Exclusion Criteria: Presence of personal or hereditary pathology. Presence of psychological or behavioral disorder. Semen parameters below those indicated in the inclusion criteria.
Where it's running
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IVI Alicante
Alicante, Alicante, Spain Recruiting
Study contacts
- Study coordinator: Elena Sellés, PhD
- Email: elena.selles@ivirma.com
- Phone: +34 966012490
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.