Adding magnesium sulfate to morphine to reduce urinary retention after cesarean section

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of adding magnesium sulfate to morphine in the epidural space to decrease the occurrence of acute urinary retention following cesarean sections. The study will involve 290 parturients who will be randomly assigned to receive either magnesium sulfate or a placebo along with morphine during their epidural anesthesia. The primary goal is to determine if this combination can reduce the incidence of urinary retention, which affects about 33% of women after cesarean delivery. Participants will be monitored post-surgery to assess urinary function and any adverse effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who have undergone scheduled or emergency Caesarean section surgery under extended epidural anesthesia or combined epidural and spinal anesthesia at the Reims University Hospital.
* Patients who have just undergone caesarean section and have the epidural catheter in place in the post-interventional monitoring room (SSPI).
* Patients who agree to take part in the research and have signed the informed consent form
* Patients of legal age
* Patients affiliated to a social security scheme

Exclusion Criteria:

* Minor patients
* Patients protected by law
* Patients allergic to local anesthetics, morphine or magnesium sulfate
* Patients with severe renal insufficiency (GFR \< 30 ml/min)
* Patients with pre-pregnancy mictional disorders
* Patients with an American Society of Anesthesiologists (ASA) score of 4
* Patients undergoing caesarean section under general anaesthesia, after failure of perimedullary anaesthesia
* Patients with accidental intraoperative injury to the urinary tract
* Patients who have received intravenous magnesium sulfate in the 24 hours preceding cesarean section

Where it's running

• Chu Reims
  Reims, France Recruiting

Study contacts

• Study coordinator: Maxime Riffault
• Email: mriffault@chu-reims.fr
• Phone: 00336 79 63 29 55

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.