Adding low-dose IV ketamine to spinal anesthesia to prolong numbness for lower-limb surgery in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Older adults scheduled for elective lower‑limb surgery under spinal anesthesia will receive standard spinal anesthesia with hyperbaric bupivacaine 0.5% and be assigned to either an IV ketamine arm (0.2 mg/kg bolus diluted to 5 ml followed by 0.1 mg/kg/hr infusion) or a placebo saline arm (5 ml bolus followed by matching infusion). The primary outcome is duration of sensory block measured by dermatome level over time after spinal injection. Secondary observations include postoperative analgesia requirements and hemodynamic/neurologic safety in the geriatric population. The protocol excludes patients with coagulopathy, preexisting neurologic disorders, local infection at the needle site, known drug allergies, or those who refuse participation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 65 years and older

  * Both sexes
  * American Society of Anesthesiologists (ASA) physical status I, II, III
  * Scheduled for elective lower limb surgeries under spinal anesthesia in supine position

Exclusion Criteria:

* Patient's refusal.

  * Pre-existing neurological disorders.
  * Coagulopathy (i.e., Platelets ≤ 60,000 and/or INR\> 1.5).
  * Localized infection at the site of needle insertion.
  * Known hypersensitivity or allergies to any of the used drugs

Where it's running

• Cairo university hospitals
  Cairo, Giza Governorate, Egypt Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gyrotonic exercise for elders with breast cancer and Behcet disease

  We’re testing whether a gyrotonic exercise program helps older people who have both Behcet disease and breast cancer.

  Recruiting Cairo University · Giza, Dokki · NCT07929116

• Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft

  This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07926516

• Virtual Reality and Mental Practice to Improve Balance and Walking in Relapsing MS

  This study tests whether virtual reality training or mental practice can improve balance and walking in people with relapsing–remitting multiple sclerosis.

  Recruiting Cairo University · Giza, Giza Governorate · NCT07918339

• Video Microscope vs Loupe-Assist in Varicocelectomy

  This study tests whether using a video telescopic operating microscope (VITOM) provides better outcomes and surgeon satisfaction than loupe-assisted varicocelectomy in adult men with grade II/III varicoceles.

  Recruiting Cairo University · Cairo · NCT07916285

• Isometric Handgrip Training Before and After Heart Surgery to Boost Recovery

  This study tests whether gentle handgrip exercise before and after open-heart surgery helps people recover their physical ability and autonomic function.

  Recruiting Cairo University · Giza · NCT07906873

• crisaborole 2% versus tacrolimus 0.1% with light therapy for facial vitiligo

  This study tests whether applying crisaborole 2% ointment can improve stable facial vitiligo in children and adults and whether it is as safe and effective as tacrolimus 0.1% when combined with light therapy.

  Recruiting Phase 3 Cairo University · Cairo · NCT07904910

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.