Adding hyaluronidase to bupivacaine for pain relief after cesarean section
Effect of Adding Two Different Doses of Hyaluronidase to Bupivacaine in Ultrasound-Guided Transversus Abdominis Plane (TAP) Block for Post-cesarean Section Analgesia; A Randomized Controlled Double Blinded Study.
This study is testing if adding hyaluronidase to a common pain relief shot can help women feel less pain after having a cesarean section.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | Benha University Academic / other |
| Locations | 1 site (Banhā, Qalubia) |
| Trial ID | NCT05671172 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of adding hyaluronidase to bupivacaine in a transversus abdominis plane (TAP) block for pain management following cesarean sections. The aim is to determine if hyaluronidase can enhance the spread of the local anesthetic, thereby improving pain relief. Participants will receive injections of varying concentrations of hyaluronidase combined with bupivacaine under ultrasound guidance. The study focuses on parturients aged 18-40 scheduled for elective cesarean sections under spinal anesthesia.
Who should consider this trial
Good fit: Ideal candidates are parturients aged 18-40 with ASA physical status grade II scheduled for elective cesarean sections.
Not a fit: Patients with ASA grade III or IV, those with complicated pregnancies, or those who are obese may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved postoperative pain management for women undergoing cesarean sections.
How similar studies have performed: While there is limited research on this specific combination, similar studies exploring local anesthetic enhancements have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * parturients who aged between 18-40 years old * with ASA physical status grade II and * scheduled for elective CS under spinal anesthesia Exclusion Criteria: * patients with ASA grade III or IV, * refusal to participate, * emergency CS or complicated pregnancy, * those with bleeding disorders or on anticoagulants, * those with severe respiratory and cardiovascular diseases, * having any local infection at the injection site, * history of allergy to one of the used drugs, * obese patients (body mass index ≥ 30 kg/m2).
Where this trial is running
Banhā, Qalubia
- Samar Rafik Amin — Banhā, Qalubia, Egypt (Recruiting)
Study contacts
- Study coordinator: Samar R Amin
- Email: samar.rafik@gmail.com
- Phone: 01287793991
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.