Adding glycerol to electrolyte drinks to improve fluid balance
Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest
This study tests if adding glycerol to sports drinks can help healthy adults stay better hydrated.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 95 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | PepsiCo Global R&D Industry-sponsored |
| Locations | 1 site (Valhalla, New York) |
| Trial ID | NCT06654557 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of adding glycerol to various carbohydrate-electrolyte beverages on fluid balance in healthy adults at rest. Participants will consume different drinks, including those with and without glycerol, and their fluid balance will be measured over a period of 120 minutes. The study consists of two parts, with a total enrollment of 95 participants, and aims to determine if glycerol can enhance fluid retention compared to placebo drinks. The findings could provide insights into optimizing hydration strategies for active individuals.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women aged 18-50 who are recreationally active and do not have any health conditions that could interfere with the study.
Not a fit: Patients with significant health conditions, such as cardiovascular or renal diseases, or those taking medications that may interfere with fluid balance will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved hydration strategies for athletes and active individuals.
How similar studies have performed: Previous studies have suggested positive effects of glycerol on fluid balance, indicating that this approach may have merit.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Subject is male or female * If female, subject is not pregnant (based on self-report) * Subject is 18-50 years of age, inclusive Subject is at least recreationally active (engaged in light to moderate intensity, intermittent, or steady-state exercise at least 3 days per week for at least 30 min at a time) * Subject does not smoke (or has quit for at least 6 months) * Subject is not taking medication that may interfere with the study (e.g., diuretics) * Subject has no health conditions that would interfere with the study, As indicated on the general health questionnaire (GHQ), e.g. cardiovascular, renal, or metabolic diseases * Subject is not allergic to adhesives (e.g., medical tape) * Subject is not allergic to kiwi-strawberry flavoring * Subject is willing to avoid alcohol consumption 24 hours prior to visit(s) * Subject is willing to fast overnight (\~8-12 hours) * Subject is willing to refrain from vigorous exercise for 24 hours (light physical activity only) * Subject is willing to eat the exact same food the day prior to each visit to the laboratory * Able to speak, write, and read English * Provision of written consent to participate Exclusion Criteria: * Subject has participated in a clinical trial within the past 30 days * Subject has participated in any PepsiCo trial within past 6 months * Subject has a condition or is taking medication that the investigator believes would interfere with his/her ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the person at undue risk * Subject is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If subject is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.
Where this trial is running
Valhalla, New York
- PepsiCo R&D, Gatorade Sports Science Institute — Valhalla, New York, United States (Recruiting)
Study contacts
- Principal investigator: Lindsay Baker, PhD — PepsiCo R&D Life Sciences, Sports Science
- Study coordinator: Lindsay Baker, PhD
- Email: Lindsay.Baker@pepsico.com
- Phone: 814-883-9454
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.