Adding cognitive training to methylphenidate for adults with ADHD and addiction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults diagnosed with ADHD and at least one addictive disorder who are appropriate for methylphenidate receive standard MPH treatment and are assigned to either an intensive cognitive remediation program using PRESCO® or a control program using AUDITICO®. The intervention combines repeated cognitive exercises targeting deficient functions with training in compensatory strategies. Functional outcomes are measured at the end of treatment and in the medium term using clinical and objective assessments. The multicenter study is conducted at several French hospital sites and requires in-person participation for the training sessions and assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18;
* Diagnosis of ADHD confirmed by DIVA-5 interview following a specialized ADHD-addiction(s) consultation;
* Indication for MPH treatment according to European recommendations (J. J. S. Kooij et al., 2019) and absence of contraindications (particularly cardiological);
* Presence of at least one comorbid addictive disorder (SUD and/or BA);
* Having given their consent to take part in the study;
* Being affiliated to the French social security system or benefiting from such a system.

Exclusion Criteria:

* Presence of disorders of the higher functions or difficulties in reading or writing the French language making it impossible to collect data;
* Pregnant or breast-feeding woman;
* Person deprived of liberty;
* Person under compulsory psychiatric care;
* Participation in another interventional research protocol involving another psychotherapeutic or pharmacological intervention that may have an impact on clinical outcome;
* Guardianship or safeguard of justice.
* Patients who consumned psychoactive substances within 12 hours prior to their visit.

Where it's running

• CHU Nantes
  Nantes, France Recruiting
• CHRU Brest
  Brest, Brittany Region, France Not yet recruiting
• EPSM du Finistère Sud
  Quimper, Brittany Region, France Not yet recruiting
• EPSM Georges Daumézon (Fleury-les-Aubrais, Loiret)
  Fleury-les-Aubrais, Centre-Val de Loire, France Not yet recruiting
• CHRU de Tours
  Tours, Centre-Val de Loire, France Not yet recruiting
• CH Georges Daumézon - Bouguenais
  Bouguenais, Loire-Atlantique, France Not yet recruiting

Study contacts

• Study coordinator: Clémence Dr Cabelguen, MD-Phd
• Email: clemence.cabelguen@chu-nantes.fr
• Phone: 33240846116

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.