Adaptive radiotherapy for patients with gynecological tumors
Prospective Randomized Validation of Adaptive Radiotherapy in Patients With Gynecological Tumors and Indication for Radiotherapy
This study is testing a new way of giving radiation therapy to women with advanced gynecological cancers to see if it can better target tumors while protecting healthy tissue.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | University Hospital, Essen Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Essen, Germany / NRW) |
| Trial ID | NCT06230549 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of adaptive radiotherapy in treating locally advanced gynecological cancers, such as cervical and endometrial carcinoma. It utilizes online-adaptive techniques to adjust radiation doses based on real-time anatomical changes before each treatment session. By employing cone-beam CT imaging, the study aims to optimize radiation delivery, ensuring that the tumor is adequately targeted while minimizing exposure to surrounding healthy tissues. The goal is to treat at least 15 patients who are not candidates for radical surgery or brachytherapy.
Who should consider this trial
Good fit: Ideal candidates are patients with locally advanced gynecological carcinoma who have an ECOG performance status of 0-1 and are not suitable for radical surgery or brachytherapy.
Not a fit: Patients with recurrent disease or those who have previously undergone pelvic radiotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and safer radiation treatments for patients with advanced gynecological tumors.
How similar studies have performed: Other studies have shown promise with adaptive radiotherapy techniques, indicating potential for success in this novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: ECOG 0-1 confirmation by histophatology MR of the pelvis staging Exclusion Criteria: Recurrent disease Prior Radiotherapy in pelvic region stage pM1 or cM1
Where this trial is running
Essen, Germany / NRW
- Department for Radiotherapy, University Hospital Essen, National Center for Tumor Diseases (NCT) West — Essen, Germany / NRW, Germany (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.