Adapalene gel versus cryotherapy for recurrent plantar warts
Official title: Comparison of Efficacy of Topical Adapalene Gel Versus Cryotherapy in Recurrent Plantar Warts
Run by Khyber Teaching Hospital · NCT07016360 · Data updated 2026-11-12
This will try topical adapalene 0.1% gel versus cryotherapy (liquid nitrogen) in adults aged 18–60 with recurrent plantar warts.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 98 (estimated) |
| Sponsor | Khyber Teaching Hospital Academic / other |
| Locations | 1 site (Peshawar, Khyber Pakhtunkhwa) |
| Status | Recruiting |
| Started | September 15, 2025 |
| Main results expected | February 15, 2026 |
| Study ends | September 15, 2026 |
| Registry record updated | April 29, 2026 |
| Trial ID | NCT07016360 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–60 with recurrent plantar warts who are not pregnant or breastfeeding, not taking immunosuppressants, not recently treated topically or systemically for warts, without local secondary infection, and with five or fewer lesions are ideal candidates.
✕Probably not a fit
Patients who are pregnant or breastfeeding, on immunosuppressants, recently treated for warts, have local secondary infection, or have more than five lesions are unlikely to be eligible or to benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This Phase 4 interventional comparison enrolls adults with recurrent plantar warts at Khyber Teaching Hospital to receive either topical adapalene 0.1% gel or periodic cryotherapy with liquid nitrogen. Participants will be treated and followed at scheduled visits to document wart clearance, recurrence, and any side effects. Eligible adults are 18–60 years old, not pregnant or lactating, not on recent topical or systemic wart therapies or immunosuppressants, and without local secondary infection or more than five lesions. The study compares clinical efficacy and tolerability of the topical retinoid versus cryotherapy to help guide routine care for recurrent plantar warts.
Why it matters
Potential benefit: If successful, the topical adapalene could provide an effective, potentially less painful and more convenient alternative to cryotherapy for recurrent plantar warts.
How similar studies have gone: Cryotherapy is an established standard treatment with known efficacy, while topical retinoids such as adapalene have shown mixed but sometimes promising results in smaller studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients age limit 18-60 Years Patients with either gender (Male/Female) Patients with recurrent plantar warts Exclusion Criteria: * Pregnancy/lactation. Pt on topical or systemic therapy in last 6 months. On immunosuppressants. \> 5 lesions. Pts with local secondary infections.
Where it's running
-
Khyber Teaching Hospital
Peshawar, Khyber Pakhtunkhwa, Pakistan Recruiting
Study contacts
- Principal investigator: Saba Naz, MBBS — Khyber Teaching Hospital
- Study coordinator: Saba Naz, MBBS
- Email: sabikhattak477@gmail.com
- Phone: +923209600115
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Antireflux stitch during one-anastomosis gastric bypass
This study will test whether adding an antireflux stitch during one-anastomosis gastric bypass reduces postoperative reflux and vomiting for patients having that surgery.
-
Early versus late laparoscopic gallbladder removal after clearing common bile duct stones with ERCP
This trial will test whether having your gallbladder removed soon after ERCP or waiting longer gives better outcomes for people who had stones cleared from their common bile duct.
-
Single chest drain versus two drains after esophagectomy
This will test whether using one chest drain instead of two helps people recover more easily after open surgery to remove esophageal cancer.
-
Perioperative bupivacaine at knee arthroscopy port sites to reduce pain and improve movement
This trial tests whether applying bupivacaine around knee arthroscopy port sites during surgery reduces postoperative port-site pain and helps patients move sooner.
-
Comparing needling and microneedling treatments for vitiligo
This study is testing whether needling or microneedling treatments, followed by light therapy, can help people with stable vitiligo see better skin color improvement.
-
Comparing microneedling treatments for acne scars
This study is testing whether microneedling with Platelet Rich Plasma or with topical insulin works better to improve acne scars in people who haven't had treatment in the last six months.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.