Adapalene gel versus cryotherapy for recurrent plantar warts
Comparison of Efficacy of Topical Adapalene Gel Versus Cryotherapy in Recurrent Plantar Warts
This will try topical adapalene 0.1% gel versus cryotherapy (liquid nitrogen) in adults aged 18–60 with recurrent plantar warts.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 98 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Khyber Teaching Hospital Academic / other |
| Locations | 1 site (Peshawar, Khyber Pakhtunkhwa) |
| Trial ID | NCT07016360 on ClinicalTrials.gov |
What this trial studies
This Phase 4 interventional comparison enrolls adults with recurrent plantar warts at Khyber Teaching Hospital to receive either topical adapalene 0.1% gel or periodic cryotherapy with liquid nitrogen. Participants will be treated and followed at scheduled visits to document wart clearance, recurrence, and any side effects. Eligible adults are 18–60 years old, not pregnant or lactating, not on recent topical or systemic wart therapies or immunosuppressants, and without local secondary infection or more than five lesions. The study compares clinical efficacy and tolerability of the topical retinoid versus cryotherapy to help guide routine care for recurrent plantar warts.
Who should consider this trial
Good fit: Adults aged 18–60 with recurrent plantar warts who are not pregnant or breastfeeding, not taking immunosuppressants, not recently treated topically or systemically for warts, without local secondary infection, and with five or fewer lesions are ideal candidates.
Not a fit: Patients who are pregnant or breastfeeding, on immunosuppressants, recently treated for warts, have local secondary infection, or have more than five lesions are unlikely to be eligible or to benefit from this comparison.
Why it matters
Potential benefit: If successful, the topical adapalene could provide an effective, potentially less painful and more convenient alternative to cryotherapy for recurrent plantar warts.
How similar studies have performed: Cryotherapy is an established standard treatment with known efficacy, while topical retinoids such as adapalene have shown mixed but sometimes promising results in smaller studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients age limit 18-60 Years Patients with either gender (Male/Female) Patients with recurrent plantar warts Exclusion Criteria: * Pregnancy/lactation. Pt on topical or systemic therapy in last 6 months. On immunosuppressants. \> 5 lesions. Pts with local secondary infections.
Where this trial is running
Peshawar, Khyber Pakhtunkhwa
- Khyber Teaching Hospital — Peshawar, Khyber Pakhtunkhwa, Pakistan (Recruiting)
Study contacts
- Principal investigator: Saba Naz, MBBS — Khyber Teaching Hospital
- Study coordinator: Saba Naz, MBBS
- Email: sabikhattak477@gmail.com
- Phone: +923209600115
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.