Clinical trial Recruiting at 1 site Interventional Ages 18 and up Women only

Acupuncture-style TENS to reduce pain and stress before and during egg retrieval

Official title: Acupuncture-type Transcutaneous Electrical Nerve Stimulation on Pain and Stress Reduction Before and During Transvaginal Ultrasound-guided Oocyte Retrieval: a Randomized Controlled Trial

Run by Chinese University of Hong Kong · NCT06910540 · Data updated 2026-11-12

This trial will test whether acupuncture-style transcutaneous electrical nerve stimulation (acu-TENS) can cut pain by half for women having transvaginal ultrasound-guided egg retrieval.

More Acupuncture trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexWomen only
Enrollment144 (estimated)
SponsorChinese University of Hong Kong
Academic / other
Locations1 site (Hong Kong)
StatusRecruiting
StartedSeptember 1, 2025
Main results expectedDecember 31, 2027
Study endsDecember 31, 2028
Registry record updatedDecember 22, 2025
Trial IDNCT06910540 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Women scheduled for transvaginal ultrasound-guided oocyte retrieval (IVF/ET cycles) who can consent and do not have major cardiac or respiratory disease and who are not current smokers or drinkers.

Probably not a fit

Patients with severe cardiac or respiratory disease, current smokers or drinkers, those ineligible for acu-TENS, or people unable to attend the Hong Kong site are unlikely to benefit from or be eligible for this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective randomized controlled trial at the Prince of Wales Hospital enrolling 144 women undergoing transvaginal ultrasound-guided oocyte retrieval who will be randomized to receive acu-TENS or a sham procedure during retrieval. Acu-TENS is delivered with a Myolito multifunctional stimulator while standard ultrasound-guided follicle aspiration is performed. The primary aim is to see if acu-TENS reduces procedural pain intensity by 50%, with pain measured during the procedure (detailed primary outcome specification not provided). The protocol excludes patients with severe cardiac or respiratory disease, current smoking or drinking, or inability/refusal to consent, and will record adverse events and postoperative pain or stress measures as secondary data.

Why it matters

Potential benefit: If successful, acu-TENS could substantially reduce pain and stress during egg retrieval and reduce reliance on other analgesics.

How similar studies have gone: Prior small studies of TENS and acupuncture-type approaches have shown benefits for some types of procedural and postoperative pain, but application specifically to transvaginal oocyte retrieval is limited and not widely confirmed.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Women undergoing IVF-ET cycles are to be recruited from the Assisted Reproduction Technology unit in the Prince of Wales Hospital

Exclusion Criteria:

* Patient not eligible for acu-TENS
* Patient with severe cardiac and respiratory disease history
* Smoker or drinker
* Refuse or incompetence for informed consent

Where it's running

  • Chung Pui Wah, Jacqueline
    Hong Kong, China
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.