Clinical trial Recruiting at 1 site Interventional Ages 18 to 75

Acupuncture for treating seasonal allergies

Official title: Effect of Acupuncture at the Sphenopalatine Ganglion in the Treatment of Moderate-to-severe Seasonal Allergic Rhinitis

Run by Guang'anmen Hospital of China Academy of Chinese Medical Sciences · NCT04815668 · Data updated 2026-11-12

This study is testing whether acupuncture can help people with moderate-to-severe seasonal allergies feel better compared to a placebo treatment and standard medication.

Quick facts

Study typeInterventional
Ages18 Years to 75 Years
SexAll
Enrollment120 (estimated)
SponsorGuang'anmen Hospital of China Academy of Chinese Medical Sciences
Academic / other
Drugs / interventionsimmunotherapy
Locations1 site (Beijing)
StatusRecruiting
StartedMay 1, 2021
Main results expectedOctober 31, 2026
Study endsDecember 31, 2026
Registry record updatedJuly 16, 2025
Trial IDNCT04815668 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 to 75 with a history of moderate to severe seasonal allergic rhinitis symptoms lasting more than four weeks.

Probably not a fit

Patients with perennial allergic rhinitis, acute sinusitis, or other significant respiratory conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of acupuncture applied at the sphenopalatine ganglion for patients suffering from moderate-to-severe seasonal allergic rhinitis. Participants will be divided into three groups: one receiving acupuncture, another receiving placebo acupuncture, and a third group using rescue medication. The study aims to assess symptom relief and overall improvement in quality of life for individuals with allergic rhinitis. The research addresses a gap in existing literature regarding the efficacy of acupuncture as a treatment option for this condition.

Why it matters

Potential benefit: If successful, this approach could provide a non-pharmacological treatment option for patients suffering from seasonal allergic rhinitis.

How similar studies have gone: While acupuncture has been used for various conditions, this specific approach targeting the sphenopalatine ganglion is relatively novel and has not been extensively tested in controlled studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Age ≥18 years and ≤ 75 years;
2. History of moderate to severe SAR symptoms (Visual analog scale(VAS) \>50 mm, range, 0 cm\[not at all bothersome\] to 100 mm\[extremely bothersome\]) for more than 4 days/weeks, and more than 4 consecutive weeks with at least two years' duration;
3. Positive skin prick test to grass and birch pollen or/and serum-specific IgE test;
4. Ability to complete the medical information form and sign a written informed consent.

Exclusion Criteria:

1. History or current evidence of perennial allergic rhinitis, acute sinusitis, allergic asthma, pneumonia; autoimmune disorders, or severe chronic inflammatory diseases;
2. History of nasal rhinopolypus or abnormalities;
3. Intake of antihistamines, anticholinergics, corticosteroids, decongestants, or antibiotics during the 1 month prior to beginning the study;
4. History of systemically administered corticosteroids within 6 months or specific immunotherapy, allergy desensitization therapy within 1 year before enrollment;
5. Serious uncontrolled blood coagulation disorder, cardiovascular disorder, severe hepatic/renal insufficiency or mental disorder;
6. Pregnancy or planning for pregnancy;
7. Known allergy, or contraindication to rescue medication or related drugs;
8. Known phobia to acupuncture or having received acupuncture treatment, or sphenopalatine ganglion stimulation or other complementary and alternative medicine within 1 months prior to enrollment.

Where it's running

  • No.731 Hospital of China Aerospace Science and Industry Corporation
    Beijing, China
    Recruiting

Study contacts

  • Principal investigator: Weiming Wang, MD,PhD — Guang'anmen Hospital of China Academy of Chinese Medical Sciences
  • Study coordinator: Weiming Wang, MD, PhD
  • Email: wangweiming1a1@163.com
  • Phone: 010-88001830

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Rupatifen Fumarate Capsules for Seasonal Allergic Rhinitis

    This Phase 3 trial tests Rupatifen Fumarate Capsules in adults with seasonal allergic rhinitis to see if they reduce symptoms compared with Rupatadine Fumarate and placebo.

    Recruiting at 18 sites Phase 3 Fujian Mindong Rejuvenation Pharmaceutical Co., Ltd. · Baoding, Hebei and 17 other locations · NCT07711262

  • TQH2722 injection plus regular allergy treatment for seasonal pollen allergy

    This trial will test whether adding TQH2722 injections to usual care helps adults (18–75) with seasonal allergic rhinitis who had poor symptom control during pollen season.

    Recruiting at 3 sites Phase 2 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Beijing, Beijing Municipality and 29 other locations · NCT07398859

  • Creating a risk assessment tool for thunderstorm asthma (CARISTA)

    This project will test whether lung tests, allergy blood markers and daily symptom tracking can predict which adults with hay fever in South‑Eastern Australia will have seasonal or thunderstorm-related asthma attacks over two spring seasons.

    Recruiting at 6 sites University of Melbourne · Albury, New South Wales and 5 other locations · NCT07055542

  • Treatment of seasonal allergic rhinitis with MG-K10 monoclonal antibody injection

    This study is testing if an injection of a new medicine called MG-K10 can help people with seasonal allergies feel better compared to a placebo.

    Recruiting Phase 2/3 Shanghai Mabgeek Biotech.Co.Ltd · Beijing, Beijing Municipality · NCT06846385

  • CM310 for uncontrolled seasonal allergic rhinitis

    This trial will try CM310, a medicine that blocks the interleukin‑4 receptor, in people whose seasonal allergic rhinitis is not well controlled by current treatments.

    Recruiting Phase 2 Beijing Tongren Hospital · Beijing, Beijing Municipality · NCT06300203

  • Evaluating the Nasal Allergen Provocation Test for Allergen Immunotherapy

    This study is trying to see how well a nasal allergy test works for people starting treatment for allergic rhinitis and if it can help improve their care over time.

    Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaam Brabant and 1 other locations · NCT04544774

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.