Acetazolamide and plasma volume changes at high altitude

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy, non-smoking men and premenopausal women aged 18–44 who were born, raised, and currently live below 1000 m are enrolled. Participants receive either acetazolamide or a matching placebo and undergo controlled high-altitude exposure with physiological measurements taken during the first 24 hours. Investigators measure plasma volume and hemoglobin concentration to characterize early fluid shifts that occur with hypoxia. Key exclusions include pregnancy or nursing, anemia, recent altitude exposure, and use of most hormonal contraceptives.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy, non-smoking men and women, age 18-44 years, without any disease and need of regular medication (including oral contraceptives).
* BMI \>18 kg/m2 and \<30 kg/m2.
* Born, raised and currently living at altitudes \<1000 m.
* Written informed consent.
* Premenopausal women with an eumenorrheic cycle.

Exclusion Criteria:

* Other types of contraceptvies (contraceptives (hormonal intrauterine device, vaginal ring, subcutaneous injections or implants, among others).
* Pregnancy or nursing
* Anaemic (haemoglobin concentration \<10g/dl).
* Any altitude trip \<4 weks before the study.
* Allergy to acetazolamide and other sulfonamides.

Where it's running

• National Center for Cardiology and Internal Medicine
  Bishkek, Kyrgyzstan Recruiting

Study contacts

• Principal investigator: Paul Robach, PhD — EXALT (Centre d'Expertise sur l'Altitude), Grenoble, France
• Study coordinator: Benoit Champigneulle, MD PhD
• Email: BChampigneulle@chu-grenoble.fr
• Phone: +33476769288

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.